Results 71 to 80 of about 54,736 (255)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Effect of Person-Organization Fit and Person-Job Fit on Performance with Organizational Citizenship Behavior as Mediation

Indonesian Interdisciplinary Journal of Sharia Economics
This research aims to examine the impact of job fit and person-organization fit on performance, using organizational citizenship behavior as a mediating factor. This study approach is quantitative.
Nila Widi Purbaningrum, Endang Tjahjaningsih   +1 more
doaj   +1 more source

The Influence of Person Job Fit and Person Organization Fit on Organizational Commitment

Formosa Journal of Applied Sciences
This research aims to analyze the influence of person job fit and person organization fit on organizational commitment (study of employees of PT. Bina Media Perintis Medan). The influence between person job fit and person organization fit will be analyzed partially and simultaneously on organizational commitment.
Cindy Eunike Harefa, Nana Dyki Dirbawanto   +1 more
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reawakening perceived person organization fit and perceived person job fit: Removing obstacles organizational commitment [PDF]

Management Science Letters, 2020
Mochamad Soelton, Noermijati Noermijati, Fatchur Rohman, Mugiono Mugiono, Irfan Noviandy Aulia, Rustam Efendi Siregar   +5 more
doaj   +1 more source

Relationship between Perceived Fit of Nurses and Organizational Citizenship Behavior in Shiraz Hospitals

Journal of Research Development in Nursing and Midwifery, 2014
Background and Objective: This study aimed to investigate the relationship between perceived fit of nurses and organizational citizenship behavior. Material and Methods: The statistical population of this correlational study was all nurses of Shiraz ...
Abdozahra Naami, Farideh Ensafdaran, Nasir Dastan, Mohammad Babamiri   +3 more
doaj  

Job and life satisfaction of apprentices: the effect of personality, social relations, and decent work

Empirical Research in Vocational Education and Training
Based on the social cognitive model and on the psychology of working theory, this research aims to study the job and life satisfaction of apprentices, considering proactive personality, person-supervisor and person-group fit, occupational self-efficacy ...
Camilla Zambelli, Jenny Marcionetti, Jérôme Rossier   +2 more
doaj   +1 more source

Person-Job Fit and Subjective Underemployment in Multinational Companies

Proceedings of the International Conference on Business Excellence, 2022
Abstract Using a multiple regression analysis, this paper studied existing links between person-job fit and subjective underemployment. Subjective underemployment is a contemporary topic especially in multinational companies, characterized by procedures that often make employees perceive themselves as un-fit with their role.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source