Results 61 to 70 of about 30,268 (263)

How Nurses’ Person-Organization Fit Influences Organizational Loyalty

, 2023
Miaomiao Sun,1,2 Fahad Alam,3 Cunxiao Ma4 1School of Ethnology and Historiography, Ningxia University, Yinchuan, People’s Republic of China; 2The Party School of the CPC, Ningxia Hui Autonomous Region Party Committee, Ningxia Administration Institute ...
Sun M, Ma C, Alam F
core  

The Impact of the Fit Between Expected and Actual Feedback on Employees’ Subsequent Voice Behavior

Systems
Background: Employee voice, as a bottom-up proactive behavior, is crucial for organizational development. However, sustaining employee voice over time remains a shared challenge for both practice and research.
Chunjie Fu, Qiongdan Xing, Yang Luo, Qian Zhang, Jiaqin Ding   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

When Does Future Work Self Predict Work Engagement: the Boundary Conditions of Person-Vocation Fit and Trust in Supervisor [PDF]

, 2019
Work engagement is a crucial positive psychological construct related to mental health. However, current self-directed and boundaryless career trend brings unprecedented challenges for organizations to foster employee engagement using traditional means ...
Guo, Ping, Zhou, Wenxia, Xu, Ying
core   +1 more source

A Cross-Level Analysis of Linking Transformational Leadership and Employee Creativity to Enhance Task Performance: The Mediating Effects of Person-Supervisor Fit and Psychological Empowerment

Journal of Human Resource and Sustainability Studies
Wann-Yih Wu
exaly   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Relationship Between Individual Personality Characteristics and Person-Job Fit Among Primary and Secondary School Teachers in New Zealand

, 2012
Research has shown that individual personality characteristics are strongly related to an employee’s affective and behavioural responses to the job and/or workplace (Barrick & Mount, 1991; Judge & Bono, 2001, Kumar & Bakhshi, 2010).
Chan, Jing Yi (Daphne)
core