Results 101 to 110 of about 1,944 (186)

Cysteine Signalling in Plant Pathogen Response

Plant, Cell &Environment, Volume 48, Issue 10, Page 7107-7122, October 2025.
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Jannis Moormann, Björn Heinemann, Cecile Angermann, Anna Koprivova, Ute Armbruster, Stanislav Kopriva, Tatjana M. Hildebrandt   +6 more
wiley   +1 more source

Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system.

Nitric oxide (NO), hydrogen sulfide and polysulfides have been proposed to contribute to redox signaling by activating the Keap-1/Nrf2 stress response system. Nitrosopersulfide (SSNO(-)) recently emerged as a bioactive product of the chemical interaction
Cortese-Krott, Miriam M., Feelisch, Martin, Pullmann, David   +2 more
core   +1 more source

Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology [PDF]

, 2020
Protein persulfidation plays a role in redox signaling as an anti-oxidant. Dimers of amyloid β42 (Aβ42), which induces oxidative stress-associated neurotoxicity as a causative agent of Alzheimer's disease (AD), are minimum units of oligomers in AD ...
Akagi, Ken-ichi, Hanaki, Mizuho, Hirose, Kenji, Irie, Kazuhiro, Kato, Haruka, Kawase, Taiji, Monobe, Yoko, Murakami, Kazuma   +7 more
core   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 222-242, June 2025.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

Trimethyl Lock Based Tools for Drug Delivery and Cell Imaging – Synthesis and Properties

Chemistry – A European Journal, Volume 31, Issue 4, January 17, 2025.
This article reviews the trimethyl lock (TML) system, focusing on its chemical synthesis, mechanisms, and biomedical applications. TML‐based conjugates are explored as potent drug delivery systems and fluorescent probes, enhancing antimicrobial treatments and cancer therapy.
Andrzej S. Skwarecki, Joanna Stefaniak‐Skorupa, Michał G. Nowak   +2 more
wiley   +1 more source

Pre- and postconditioning the heart with hydrogen sulfide (H2S) against ischemia/reperfusion injury in vivo: a systematic review and meta-analysis [PDF]

, 2017
Conditioning-like infarct limitation by enhanced level of hydrogen sulfide (H2S) has been demonstrated in many animal models of myocardial ischemia/reperfusion injury (MIRI) in vivo. We sought to evaluate the effect of H2S on myocardial infarction across
Baxter, Gary F., Bice, Justin S., Karwi, Qutuba G.   +2 more
core   +1 more source

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation. [PDF]

Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing lifespan extension and enhanced ...
D'Andrea, Davide, Jovanovic, Vladimir M., Kyriaki Drekolia, Maria, Miljkovic, Jan Lj, Paikopoulos, Yiorgos, Petrovic, Dunja, Savic, Nevena, Slade, Luke, Stancic, Ana, Vignane, Thibaut   +9 more
core   +5 more sources

The Activity of YCA1 Metacaspase Is Regulated by Reactive Sulfane Sulfur via Persulfidation in Saccharomyces cerevisiae

Antioxidants
YCA1, the only metacaspase in Saccharomyces cerevisiae, plays important roles in the regulation of chronological lifespan, apoptosis, and cytokinesis. YCA1 has protein hydrolase activity and functions by cleaving itself and target proteins.
Qingda Wang, Xiaokun Zhang, Zhuang Du, Honglei Liu, Yongzhen Xia, Luying Xun, Huaiwei Liu   +6 more
doaj   +1 more source

Plant H2S and Transcription Factors (TFs) Interactions: Unexplored Area

Frontiers in Bioscience-Landmark
Plant hydrogen sulfide (H2S) metabolism has garnered noteworthy attention due to its role in regulating many plant processes. The primary mechanism by which H2S exerts its signaling functions is through its reversible interaction with thiol groups on ...
Francisco J Corpas
doaj   +1 more source