Results 21 to 30 of about 1,944 (186)

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity [PDF]

Redox Biology
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
doaj   +2 more sources

Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation [PDF]

Redox Biology
Background: The binding of endothelin-1 (ET-1) to endothelin type A receptor (ETAR) performs a critical action in pulmonary arterial smooth muscle cell (PASMC) proliferation leading to pulmonary vascular structural remodeling.
Yanan Zhang, Xiaoyu Tian, Liangyi Chen, Shiqun Zhao, Xinjing Tang, Xin Liu, Dan Zhou, Chaoshu Tang, Bin Geng, Junbao Du, Hongfang Jin, Yaqian Huang   +11 more
doaj   +2 more sources

H₂S-Mediated GH3.1 Persulfidation Regulates IAA Homeostasis to Enhance Nodulation Formation and Nitrogen Fixation in Robinia pseudoacacia. [PDF]

Mol Plant Pathol
H2S persulfidates GH3.1 at Cys304, reducing its activity, sustaining IAA levels, triggering H2S‐IAA feedback, enhancing nodulation gene expression, boosting nodule formation, nitrogen fixation and Robinia pseudoacacia growth. ABSTRACT Hydrogen sulphide (H2S), a gaseous signalling molecule, plays a multifaceted role in plant physiology by enhancing ...
Zhang W, Cheng H, Yan X, Suo B, Wen S, Liu W, Wei G, Chen J.   +7 more
europepmc   +2 more sources

Proteomics Profiling of S-sulfurated Proteins in Acinetobacter baumannii

Bio-Protocol, 2021
Hydrogen sulfide (H2S) is emerging as an important modulator in bacterial cytoprotection against the host immune response in infected animals, which may well be attributed to downstream highly oxidized sulfur species, termed reactive sulfur species (RSS),
Brenna Walsh, David Giedroc
doaj   +1 more source

Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase. [PDF]

Plant Biotechnol J
Summary Root development is crucial for the growth and yield of horticultural crops. Hydrogen sulfide (H2S), an important gasotransmitter, has been shown to regulate lateral root (LR) formation in plants, including peach (Prunus persica). However, its specific regulatory mechanism remains largely unclear.
Wu X, Du A, Liang J, Wang Z, Xiao Y, Peng F.   +5 more
europepmc   +2 more sources

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Angewandte Chemie, 2022
AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick   +5 more
openaire   +2 more sources

Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.

PLoS Biology, 2021
Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary infections, termed "aspergilloses," in individuals suffering immune imbalances or underlying lung conditions.
Monica Sueiro-Olivares, Jennifer Scott, Sara Gago, Dunja Petrovic, Emilia Kouroussis, Jasmina Zivanovic, Yidong Yu, Marlene Strobel, Cristina Cunha, Darren Thomson, Rachael Fortune-Grant, Sina Thusek, Paul Bowyer, Andreas Beilhack, Agostinho Carvalho, Elaine Bignell, Milos R Filipovic, Jorge Amich   +17 more
doaj   +1 more source

Direct Proteomic Mapping of Cysteine Persulfidation [PDF]

Antioxidants & Redox Signaling, 2020
Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a potential redox mechanism to regulate protein functions and diverse biological processes in hydrogen sulfide (H2S) signaling. Due to its intrinsically unstable nature, working with this modification has proven to be challenging.
Ling, Fu, Keke, Liu, Jingyang, He, Caiping, Tian, Xiaobo, Yu, Jing, Yang   +5 more
openaire   +2 more sources

Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors

STAR Protocols, 2022
Hydrogen sulfide (H2S) and downstream reactive sulfur species (RSS), including organic persulfides, protect bacterial cells against diverse oxidative stressors. Specialized dithiol-based transcriptional repressors sense persulfides directly to control cellular H2S/RSS and avoid toxicity.
Joseph N. Fakhoury, Daiana A. Capdevila, David P. Giedroc   +2 more
openaire   +4 more sources

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

Frontiers in Aging Neuroscience, 2021
Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognized gasotransmitter. Numerous studies have revealed the role of H2S as a redox signaling molecule that controls important physiological/pathophysiological functions.
Dunja Petrovic, Emilia Kouroussis, Thibaut Vignane, Milos R. Filipovic   +3 more
doaj   +1 more source