Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides [PDF]
Angewandte Chemie - International EditionUsing isolated dichalcogenides as precursors, we report the synthesis, characterization, and reactivity of Zn persulfide and thioselenide complexes. 77Se NMR shows distinct impacts to electronic structure and reactivity between different thioselenides coordinated to different Lewis acids.
Michael Pluth
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Antioxidants, 2023 Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Akira Nishimura +2 more
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How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology [PDF]
Redox Biology, 2023 In an attempt to understand the cellular mechanisms of H2S signalling, recent research has focused on supersulfide (i.e., alkyl and inorganic hydropersulfide) formation and subsequent reactivity.
Christopher H. Switzer
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Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]
Frontiers in PhysiologyReactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi +6 more
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Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease [PDF]
Current Issues in Molecular BiologyReactive sulfur species (RSS)—hydrogen sulfide (H2S), low-molecular-weight persulfides/polysulfides and protein persulfidation—constitute a third redox axis alongside ROS and RNS.
Celia María Curieses Andrés +5 more
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Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples [PDF]
Nature CommunicationsH2S reversibly modifies low molecular weight (LMWSH) and protein (PrSH) thiols to form persulfides (RSS−) and polysulfides (RS(S)nS−) for antioxidant defence and regulation of activity.
Jan Lj. Miljkovic +12 more
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Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation [PDF]
AntioxidantsThe oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (H2S) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching
Zhichao Liu +2 more
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Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity [PDF]
Redox BiologyUnfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
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Reactive sulfur species are inactivated and excreted as trimethylsulfonium ion by thiopurine S-methyltransferase [PDF]
Redox BiologyReactive sulfur species (RSS) play essential roles in cellular signaling, redox regulation, and defense against electrophilic stress. However, excessive RSS are cytotoxic and must be strictly regulated.
Yasunori Fukumoto +11 more
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Sulfite oxidase deficiency causes persulfidation loss and hydrogen sulfide release [PDF]
The Journal of Clinical InvestigationSulfite oxidase (SOX) deficiency is a rare inborn error of cysteine metabolism resulting in severe neurological damage. In patients, sulfite accumulates to toxic levels, causing a rise in the downstream products S-sulfocysteine, which mediates ...
Chun-Yu Fu +23 more
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