Results 11 to 20 of about 1,224 (162)

Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors

STAR Protocols, 2022
Summary: Hydrogen sulfide (H2S) and downstream reactive sulfur species (RSS), including organic persulfides, protect bacterial cells against diverse oxidative stressors.
Joseph N. Fakhoury, Daiana A. Capdevila, David P. Giedroc   +2 more
doaj   +4 more sources

Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress [PDF]

Redox Biology
Acute inflammatory responses often involve the production of reactive oxygen and nitrogen species by innate immune cells, particularly macrophages. How activated macrophages protect themselves in the face of oxidative-inflammatory stress remains a long ...
Talal Salti, Ilana Braunstein, Yael Haimovich, Tamar Ziv, Moran Benhar   +4 more
doaj   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. [PDF]

Microbiol Immunol
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T.   +9 more
europepmc   +2 more sources

Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure. [PDF]

Drug Test Anal
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Sieber PH, Steinritz D, Worek F, John H.
europepmc   +2 more sources

New role for thioredoxins in plants: Implication of TRXo1 in protein depersulfidation [PDF]

Redox Biology
Persulfidation, a posttranslational modification of cysteines to persulfides, is the best characterized molecular mechanism of H2S signaling. This study is focused on new functions for thioredoxins (TRXs) in plants beyond those of thiol disulfide (S–S ...
Sabrina De Brasi-Velasco, Angeles Aroca, Luis C. Romero, Cecilia Gotor, Francisca Sevilla, Ana Jiménez   +5 more
doaj   +2 more sources

Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin–AhR–Mitochondrial Axis [PDF]

Antioxidants
Chronic kidney disease (CKD) affects approximately 700 million people worldwide and is a major contributor to end-stage renal disease (ESRD), cardiovascular morbidity, and premature mortality. Although oxidative stress has long been considered central to
Kuo-Cheng Lu, Chia-Chao Wu, Te-Chao Fang, Yi-Chou Hou, Cai-Mei Zheng, Chien-Lin Lu   +5 more
doaj   +2 more sources

Possible molecular basis of the biochemical effects of cysteine-derived persulfides

Frontiers in Molecular Biosciences, 2022
Persulfides (RSSH/RSS−) are species closely related to thiols (RSH/RS−) and hydrogen sulfide (H2S/HS−), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds.
Ernesto Cuevasanta, Ernesto Cuevasanta, Ernesto Cuevasanta, Dayana Benchoam, Dayana Benchoam, Dayana Benchoam, Jonathan A. Semelak, Matías N. Möller, Matías N. Möller, Ari Zeida, Ari Zeida, Madia Trujillo, Madia Trujillo, Beatriz Alvarez, Beatriz Alvarez, Darío A. Estrin   +15 more
doaj   +1 more source

Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics

Frontiers in Microbiology, 2023
A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack.
Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa   +17 more
doaj   +1 more source

Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells

Redox Biology, 2021
The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues.
Christopher H. Switzer, Sebastian Guttzeit, Thomas R. Eykyn, Philip Eaton   +3 more
doaj   +1 more source

The role of sulfur compounds in chronic obstructive pulmonary disease

Frontiers in Molecular Biosciences, 2022
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that brings about great social and economic burden, with oxidative stress and inflammation affecting the whole disease progress. Sulfur compounds such as hydrogen sulfide (H2S),
Simin Jiang, Yahong Chen
doaj   +1 more source