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Guided tissue regeneration: porcine matrix does not transmit PERV
Biomaterials, 2004For cardiovascular tissue engineering, acellularized scaffolds of porcine matrices have been successfully used. However, the possibility of porcine endogenous retrovirus (PERV) transmission remains debatable. In this study, we investigated whether acellularized porcine vascular scaffolds cause cross-species transmission of PERV in a xenogenic model ...
Klaus, Kallenbach +8 more
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New Insights into Porcine Endogenous Retrovirus (PERV)
2022Xenotransplantation with porcine organs has been recognized as a promising solution to alleviate the shortage of organs for human transplantation. Porcine endogenous retrovirus (PERV), whose proviral DNAs are buried in the genome of all pig breeds, is a main microbiological risk for xenotransplantation.
yu liu, Yifan Niu, Tao Wang, Dong Niu
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Science, 2017
Genome Engineering With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans. The challenge is that the pig genome harbors porcine endogenous retroviruses (PERVs) that can potentially pass ...
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Genome Engineering With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans. The challenge is that the pig genome harbors porcine endogenous retroviruses (PERVs) that can potentially pass ...
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Is Porcine Endogenous Retrovirus (PERV) Transmission Still Relevant?
Transplantation Proceedings, 2008Xenotransplantation using porcine cells or organs may be associated with the risk of transmission of zoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a potentially high risk because they are integrated into the genome of all pigs and PERV-A and PERV-B at least, which are present in all pigs, can infect human cells.
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Reappraisal of biosafety risks posed by PERVs in xenotransplantation
Reviews in Medical Virology, 2007AbstractDonor materials of porcine origin could potentially provide an alternative source of cells, tissues or whole organs for transplantation to humans, but is hampered by the health risk posed by infection with porcine viruses. Although pigs can be bred in such a way that all known exogenous microorganisms are eliminated, this is not feasible for ...
Louz, D +3 more
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Writer as perv: bricolage, bowerbirding, observation
New Writing, 2016ABSTRACTRecently it was suggested that my creative method (bowerbirding, bricolage, engaged observation) might properly be described as ‘perving’. Affronted, I rejected this accusation. But the idea wouldn’t go away, a question remained. How does observation that informs a story differ from perving or voyeurism?
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Genome-Wide PERV Inactivation in Pigs Using CRISPR/Cas9
2020The shortage of organs for transplantation is probably the biggest unmet medical need. A potential problem with the clinical use of porcine xenografts is the risk that porcine endogenous retroviruses (PERVs) could infect human cells. In the past, we determined the PERV copy number in the porcine kidney epithelial cell line PK15 and in primary ...
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Porcine pathogens and xenotransplantation: PERV and beyond!
Xenotransplantation, 2010Concerns regarding the transmission of potentially zoonotic porcine viruses via a xenotransplant have prompted a significant number of studies on methods to eliminate or prevent expression and transmission of these viruses. The main focus of these studies, to date, has been the porcine endogenous retrovirus (PERV); PERV is a genetically acquired ...
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