Results 41 to 50 of about 150,978 (251)

Nitrogen availability shapes evolution of phage resistance in cyanobacteria. [PDF]

ISME J
Abstract Nitrogen-fixing cyanobacteria play a key role in nitrogen and carbon biogeochemical cycles in aquatic ecosystems. Under nitrogen-limited conditions, their ability to fix nitrogen provides an advantage over other species and enables them to form harmful blooms, which are increasing in frequency and negatively impact aquatic ...
Higazi M, Kolan D, Cattan-Tsaushu E, Freiman Z, Ninio S, Avrani S.   +5 more
europepmc   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Whole genome sequence analysis of multi-drug resistant and biofilm-forming Staphylococcus haemolyticus isolated from bovine milk

BMC Microbiology
Background Milk is an excellent growth medium for microorganisms due to its nutritive composition. Microorganisms have been implicated in bovine mastitis (BM) in dairy cows as well as causing infections in animals and humans. Despite extensive endeavours
Daniel Jesuwenu Ajose, Tesleem Olatunde Abolarinwa, Bukola Opeyemi Oluwarinde, Peter Kotsoana Montso, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba   +6 more
doaj   +1 more source

Phage resistance profiles of AB-phages treated Acinetobacter baumannii: implications for phage therapy strategies

Journal of Infection in Developing Countries
Introduction: Phage therapy is a promising alternative for combating multidrug-resistant bacteria, including Acinetobacter baumannii (AB). However, the development of phage-resistant variants after treatment, particularly when using phage cocktails ...
Tirasak Pasharawipas, Warunya Woradulayapinij, Runtikan Pochairach, Umaporn Yordpratum   +3 more
doaj   +1 more source

CRISPR-mediated phage resistance and the ghost of coevolution past [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2010
The past is never dead. It's not even pastWilliam Faulkner (1951)Bacteria can acquire heritable immunity to viral (phage) enemies by incorporating phage DNA into their own genome. This mechanism of anti-viral defence, known by the acronym CRISPR, simultaneously stores detailed information about current and past enemies and the evolved resistance to ...
Vale, Pedro; id_orcid 0000-0003-4558-9202, Little, Tom J.   +1 more
openaire   +3 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Design combinations of evolved phage and antibiotic for antibacterial guided by analyzing the phage resistance of poorly antimicrobial phage

Microbiology Spectrum, 2023
Although antibiotics are the primary method against bacterial infections, the rapid emergence of antibiotic resistance has forced interest in alternative antimicrobial strategies.
Zhenhe Xu, Zihan Ding, Lijia Shi, YuZhen Xie, Yuanxing Zhang, Shuai Sao, Qiyao Wang, Qin Liu   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Combating antibiotic resistance in a one health context: a plethora of frontiers

One Health Outlook
One of the most significant medical advancements of the 20th century was the discovery of antibiotics, which continue to play a vital tool in the treatment and prevention of diseases in humans and animals. However, the imprudent use of antibiotics in all
Daniel Jesuwenu Ajose, Abimbola Olumide Adekanmbi, Nor Fadhilah Kamaruzzaman, Collins Njie Ateba, Shamsaldeen Ibrahim Saeed   +4 more
doaj   +1 more source