Results 61 to 70 of about 114,213 (298)
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Advanced Healthcare Materials, EarlyView.Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Molecules, 2011 Since the initial description of phage display technology for the generation of human antibodies, a variety of selection methods has been developed. The most critical parameter for all in vitro-based approaches is the quality of the antibody library ...
Kathrin Tissot +3 more
doaj +1 more source
Beyond Helper Phage: Using "Helper Cells" to Select Peptide Affinity Ligands. [PDF]
PLoS ONE, 2016 Peptides are important affinity ligands for microscopy, biosensing, and targeted delivery. However, because they can have low affinity for their targets, their selection from large naïve libraries can be challenging.
M Lisa Phipps +9 more
doaj +1 more source
Protein chainmail variants in dsDNA viruses. [PDF]
, 2015 First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core +2 more sources
Eliminating helper phage from phage display [PDF]
Nucleic Acids Research, 2006 Phage display technology involves the display of proteins or peptides, as coat protein fusions, on the surface of a phage or phagemid particles. Using standard technology, helper phage are essential for the replication and assembly of phagemid particles, during library production and biopanning. We have eliminated the need to add helper phage by using '
Chasteen, L. +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. [PDF]
, 2016 Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the memory humoral response against IsdB, a protein involved in iron acquisition, in four healthy ...
Abdiche, Yasmina +17 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez +4 more
wiley +1 more source
Phage Therapy: Past، Present and Future [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī YazdIntroduction: As viral agents، phages serve a significant purpose in molecular biotechnology. These viruses are considered as ideal tools in this field and recent studies revealed their wide potential in biomedicine.
Farzaneh Fathi, Mehdi Zeinoddini
doaj
Exploring the Secretomes of Microbes and Microbial Communities Using Filamentous Phage Display
Frontiers in Microbiology, 2016 Microbial surface and secreted proteins (the secretome) contain a large number of proteins that interact with other microbes, host and/or environment. These proteins are exported by the coordinated activities of the protein secretion machinery present in
Dragana eGagic +7 more
doaj +1 more source