Results 171 to 180 of about 150,978 (251)

Phage resistance of Bordetella avium due to an altered cell wall results in increased susceptibility to the polypeptide antibiotics colistin and polymyxin B. [PDF]

Sci Rep
Serian D, Churin Y, Hammerl JA, Jung A, Yue M, Müller A, Kehrenberg C.   +6 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Nitrogen availability shapes evolution of phage resistance in cyanobacteria. [PDF]

ISME J
Higazi M, Kolan D, Cattan-Tsaushu E, Freiman Z, Ninio S, Avrani S.   +5 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Efficacy of Ccombody as an Immunoprophylaxis Strategy: Impact on Immune Gene Expression of Pacific White Shrimp (Penaeus vannamei) Against Acute Hepatopancreatic Necrosis Disease (AHPND)

Journal of Fish Diseases, EarlyView.
ABSTRACT Acute hepatopancreatic necrosis disease (AHPND) is caused by a plasmid bearing strain of Vibrio parahaemolyticus (VpAHPND), which produces PirA and PirB toxins that specifically target and damage hepatopancreatic and epithelial cells of the shrimp gastrointestinal tract.
Prawporn Thaijongrak, Kasemsuk Kitisriworapun, Theerapat Damrongsakul, Napat Huttayanan, Thitipan Juntong, Andrew P. Shinn, Tae Sung Jung, Surasak Jittakhot, Wanna Sirimanapong   +8 more
wiley   +1 more source

Development and Application of a Novel qPCR Assay for Quantifying Flavophage FpV‐4 Against Flavobacterium psychrophilum

Journal of Fish Diseases, EarlyView.
ABSTRACT Bacteriophage (phage) therapy is increasingly being used to control Flavobacterium psychrophilum impacts upon the health and production of salmonid aquaculture worldwide, and FpV‐4 is a phage commonly utilised for the mitigation of F. psychrophilum outbreaks. While quantitative PCR (qPCR) methods are often used for quantifying F. psychrophilum,
Louise James, Tamsyn M. Uren Webster, Benjamin Overland, Arun M Shankregowda, Gethin Thomas, Mathias Middelboe, Valeria Ruffo, Sofia Consuegra   +7 more
wiley   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source