Results 1 to 10 of about 150,829 (111)

Phenotypic heterogeneity and genetic mechanisms of phage resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae [PDF]

Virulence
Phage resistance represents a major obstacle to the clinical application of phage therapy for multidrug-resistant bacterial pathogens. A comprehensive understanding of the phenotypic heterogeneity and molecular mechanisms underlying phage resistance is ...
Ye Huang, Yichen Liu, Shimin Chen, Ziyue Fan, Lili Yan, Fanglin Zheng, Dandan Wei, Yang Liu, Xinping Xu   +8 more
doaj   +2 more sources

Genome-wide transposon screening uncovers phage resistance mechanisms and bidirectional effects on antibiotic susceptibility in carbapenem-resistant Klebsiella pneumoniae [PDF]

Antimicrobial Agents and Chemotherapy
Phage therapy and phage-antibiotic combinations are promising strategies against multidrug-resistant pathogens like carbapenem-resistant Klebsiella pneumoniae (CRKP).
Zhichen Zhu, Tengfei Long, Bingjie Wang, Weijia Ding, Yuxin Yan, Yicheng Wen, Yapin Zhao, Jie Zhu, Liang Wang, Jinnan Lv, Barry N. Kreiswirth, Hong Du, Liang Chen   +12 more
doaj   +2 more sources

Investigating the phenotypic alterations associated with hypermucoviscous hypervirulent Klebsiella pneumoniae during phage resistance development [PDF]

BMC Microbiology
Phage therapy has been explored and used compassionately in the post-antibiotic era, though phage resistance might pose a serious challenge. The advent of hypervirulent and hypermucoviscous traits in Klebsiella pneumoniae limits therapeutic choices. This
Ramya Juliet, Ramesh Nachimuthu
doaj   +2 more sources

Biocontrol of Phage Resistance in Pseudomonas Infections: Insights into Directed Breaking of Spontaneous Evolutionary Selection in Phage Therapy [PDF]

Viruses
Phage therapy, long overshadowed by antibiotics in Western medicine, has a well-established history in some Eastern European countries and is now being revitalized as a promising strategy against antimicrobial resistance (AMR).
Jumpei Fujiki, Daigo Yokoyama, Haruka Yamamoto, Nana Kimura, Manaho Shimizu, Hinatsu Kobayashi, Keisuke Nakamura, Hidetomo Iwano   +7 more
doaj   +2 more sources

Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae [PDF]

Communications Biology
Phage therapy is a promising antibacterial strategy against the antibiotic resistance crisis. The evolved phage resistance could pose a big challenge to clinical phage therapy.
Yu Fu, Ming Yin, Li Cao, Yanjun Lu, Ying Li, Luhua Zhang   +5 more
doaj   +2 more sources

Adapting a Phage to Combat Phage Resistance

Antibiotics, 2020
Phage therapy is becoming a widely recognized alternative for fighting pathogenic bacteria due to increasing antibiotic resistance problems. However, one of the common concerns related to the use of phages is the evolution of bacterial resistance against
Kati Mäkelä, Janne J Ravantti, Lotta-Riina Sundberg   +2 more
exaly   +3 more sources

Overcoming phage resistance: efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii [PDF]

Microbiology Spectrum
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major public health threat due to high mortality and limited treatment options. Bacteriophage (phage) therapy offers a promising alternative, but its long-term efficacy is challenged by the rapid ...
Yoon-Jung Choi, Md Shamsuzzaman, Chaewon Park, Shukho Kim, Minsang Shin, Jungmin Kim   +5 more
doaj   +2 more sources

Multisite binding of bacteriophages on lipopolysaccharides in Escherichia coli O157:H7 and the adaptive costs of phage resistance [PDF]

Microbiology Spectrum
Escherichia coli (E. coli) O157:H7 is a major foodborne pathogen and a critical global food safety concern. Bacteriophage (phage) therapy offers a promising, highly specific biological alternative to antibiotic treatment.
Yang Wang, Jing Li, Yuhan Zhang, Yao Li, Xinru Chen, Jiaqi Cui, Feng Xue, Jianluan Ren, Jianjun Dai, Fang Tang   +9 more
doaj   +2 more sources

Insertion sequence-mediated phage resistance contributes to attenuated colonization of cytolytic Enterococcus faecalis variants in the gut [PDF]

Microbiology Spectrum
Specific elimination of cytolytic Enterococcus faecalis from the intestinal microbiota by bacteriophages (phages) attenuates ethanol-induced liver disease in pre-clinical studies; however, other clinical phage therapy studies have reported the occurrence
Jumpei Fujiki, Tomohiro Nakamura, Henriette Kreimeyer, Cristina Llorente, Derrick E. Fouts, Bernd Schnabl   +5 more
doaj   +2 more sources

Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review

Frontiers in Microbiology, 2022
Diarrhea is a condition in which feces is discharged from the bowels frequently and in a liquid form. It is one of the frequent causes of morbidity and mortality in developing countries.
Tesleem Olatunde Abolarinwa, Daniel Jesuwenu Ajose, Bukola Opeyemi Oluwarinde, Justine Fri, Kotsoana Peter Montso, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba   +7 more
doaj   +1 more source