Results 81 to 90 of about 219,803 (412)

Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
This study introduces a novel HCC treatment using poly lactic‐co‐glycolic acid (PLGA) nanoparticles encased in HCC cell membranes to co‐deliver Lenvatinib and FePt nanoparticles. This approach improves treatment efficacy by enhancing ferroptosis and apoptosis.
Feichao Xuan, Xingyang Zhao, Weiran Pang, Zirong Li, Xiangyi Yin, Weizhong Xie, Xiaojun Zeng, Liming Nie, Junying Yang, Shiying Li, Puxiang Lai, Chihua Fang   +11 more
wiley   +1 more source

Interrogating the impact of aggregation‐induced emission nanoparticles on in vitro protein stability, ex vivo protein homeostasis, and in vivo biocompatibility

Aggregate, Volume 3, Issue 6, December 2022., 2022
Investigation of how the AIE molecules and functionalized AIE nanoparticle impact protein stability, protein homeostasis in cells, biodistribution, and biocompatibility in animal model. Abstract Aggregation‐induced emission (AIE) materials offer promising perspectives in disease diagnosis and therapeutics given their unique optical and photochemical ...
Wang Wan, Qun Zhao, Biao Jing, Congcong Peng, Mengdie Wang, Yanan Huang, Wenhan Jin, Bowen Zhong, Zhenduo Zhang, Xuepeng Dong, Zhenming Gao, Lihua Zhang, Yu Liu   +12 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Unresolved excess accumulation of myelin-derived cholesterol contributes to scar formation after spinal cord injury [PDF]

arXiv, 2022
Background: Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete tissue repair. Scar formation is generally considered as a barrier for regeneration in central nervous system (CNS), while the intrinsic mechanism of scar-forming after spinal cord injury has not been completed deciphered ...
arxiv  

CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis

Multiple Sclerosis, 2018
Background: Phagocytes, such as macrophages and microglia, are key effector cells in the pathophysiology of multiple sclerosis (MS). It is widely accepted that they instigate and promote neuroinflammatory and neurodegenerative events in MS. An increasing
Jeroen F. J. Bogie, E. Boelen, Els Louagie, P. Delputte, D. Elewaut, J. van Horssen, Jerome J. A. Hendriks, N. Hellings   +7 more
semanticscholar   +1 more source

The phagocytic capacity of neurones

European Journal of Neuroscience, 2007
AbstractPhagocytosis is defined as the ingestion of particulates over 0.5 µm in diameter and is associated with cells of the immune system such as macrophages or monocytes. Neurones are not generally recognized to be phagocytic. Using light, confocal, time‐lapse and electron microscopy, we carried out a wide range of in‐vitro and in‐vivo experiments to
Bowen, Samantha, Ateh, Davidson D., Deinhardt, Katrin, Bird, Margaret M., Price, Karen M., Baker, Cathy S., Robson, Joanna C., Swash, Michael, Shamsuddin, Wassim, Kawar, Shalini, El-Tawil, Tariq, Roos, Jesper, Hoyle, Andrew, Nickols, Carole D., Knowles, Charles H., Pullen, Anthony H., Luthert, Philip J., Weller, Roy O., Hafezparast, Majid, Franklin, Robin J.M., Revesz, Tamas, King, Rosalind H.M., Berninghausen, Otto, Fisher, Elizabeth M.C., Schiavo, Giampietro, Martin, Joanne E.   +25 more
openaire   +4 more sources

The generation of oxygen radicals during host plant responses to infection [PDF]

, 1991
Recent evidence points to significant oxygen radical production by some plant tissues in response to pathogenic challenge. These findings have proved quite controversial, in part because of an inadequate appreciation of the behaviour of oxygen radicals ...
Sutherland, Mark W.
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses

Frontiers in Immunology, 2019
Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody–antigen immune ...
Matthew Zirui Tay, Kevin Wiehe, Justin Pollara, Justin Pollara   +3 more
doaj   +1 more source

A mouse ear skin model to study the dynamics of innate immune responses against the microsporidian Encephalitozoon cuniculi

Frontiers in Microbiology, 2023
Microsporidia are obligate intracellular parasites related to fungi that cause severe infections in immunocompromised individuals. Encephalitozoon cuniculi is a microsporidian species capable of infecting mammals, including human and rodents. In response
Eugénie Carriere, Aizat Iman Abdul Hamid, Inès Feki, Aurore Dubuffet, Frédéric Delbac, Pascale Gueirard   +5 more
doaj   +1 more source