Results 51 to 60 of about 50,774 (237)
Frontiers in Immunology, 2023 Phagosome acidification and proteolysis are essential processes in the immune response to contain and eliminate pathogens. In recent years, there has been an increased desire for a rapid and accurate method of assessing these processes in real-time. Here,
Alba Méndez-Alejandre +4 more
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Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria [PDF]
, 2016 Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact.
Good, L, Kamaruzzaman, N F, Kendall, S L
core +1 more source
Leishmania braziliensis: Strain-Specific Modulation of Phagosome Maturation
Frontiers in Cellular and Infection Microbiology, 2019 Leishmania (Viannia) braziliensis is responsible for the largest number of American tegumentary leishmaniasis (ATL) in Brazil. ATL can present several clinical forms including typical (TL) and atypical (AL) cutaneous and mucocutaneous (ML) lesions.
Tamara da Silva Vieira +7 more
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Francisella tularensisPhagosomal Escape Does Not Require Acidification of the Phagosome [PDF]
Infection and Immunity, 2009 ABSTRACTFollowing uptake,Francisella tularensisenters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake,F. tularensisdisrupts its phagosomal membrane and escapes into the cytoplasm.
Clemens, Daniel L +2 more
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Biochemistry of the Phagosome: The Challenge to Study a Transient Organelle
The Scientific World Journal, 2011 Phagocytes are specialized cells of the immune system, designed to engulf and destroy harmful microorganisms inside the newly formed phagosome. The latter is an intracellular organelle that is transformed into a toxic environment within minutes and ...
Oliver Nüsse
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Leishmania promastigotes: building a safe niche within macrophages
Frontiers in Cellular and Infection Microbiology, 2012 Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG).
Neda eMoradin, Albert eDescoteaux
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The Mycobacterium tuberculosis Phagosome [PDF]
, 2008 Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms ...
Esteban A, Roberts, Vojo, Deretic
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By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
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Frontiers in ImmunologyIntroductionTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality worldwide. A crucial factor in Mtb's virulence is the ESX-5 secretion system, which transports PE/PPE proteins such as PE18 and PPE26.
Aquib Ehtram +11 more
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Frontiers in Cellular and Infection Microbiology, 2010 The tularemia-causing bacterium Francisella tularensis is a facultative intracellular organism with a complex intracellular lifecycle that ensures its survival and proliferation in a variety of mammalian cell types, including professional phagocytes ...
Audrey eChong, Jean eCelli
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