Results 111 to 120 of about 36,298 (238)

ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages

Cell Reports, 2015
Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting the skin, joints, and nervous system. Macrophages and dendritic cells counteract Borrelia dissemination through internalization and degradation of spirochetes.
Xenia Naj, Stefan Linder
doaj   +1 more source

Graphene oxide nanoribbons induce autophagic vacuoles in neuroblastoma cell lines [PDF]

, 2016
Since graphene nanoparticles are attracting increasing interest in relation to medical applications, it is important to understand their potential effects on humans. In the present study, we prepared graphene oxide (GO) nanoribbons by oxidative unzipping
Fico, Flavia, Lococo, Emanuela, Mardente, Stefania, Mari, Emanuela, Morgante, Emanuela, Tafani, Marco, Valentini, Federica, Zicari, Alessandra   +7 more
core   +2 more sources

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes

eLife, 2018
Candida albicans hyphae can reach enormous lengths, precluding their internalization by phagocytes. Nevertheless, macrophages engulf a portion of the hypha, generating incompletely sealed tubular phagosomes.
Michelle E Maxson, Xenia Naj, Teresa R O'Meara, Jonathan D Plumb, Leah E Cowen, Sergio Grinstein   +5 more
doaj   +1 more source

Drug delivery systems for potential treatment of intracellular bacterial infections. [PDF]

, 2010
Despite the advent of a considerable number of new antibiotics, treatment of intracellular pathogens still represents a major pharmaceutical challenge.
Ariza, J. (J.), Blanco-Prieto, M.J. (María José), Gamazo, C. (Carlos), Imbuluzqueta, E. (Edurne)   +3 more
core   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Patterns, receptors and signals:regulation of phagosome maturation [PDF]

, 2017
Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called
Akira, Al-Haddad, Allan, Alloatti, Anne-Marie Pauwels, Arandjelovic, Axelrod, Bain, Balce, Blander, Blander, Blocker, Bohdanowicz, Boulais, Buschow, Campbell-Valois, Campisi, Canton, Cebrian, Cebrian, Cemma, Coers, Cosson, Crespo, Damiani, De Keijzer, Delamarre, Desjardins, Desjardins, Dill, Duclos, Dykstra, Eik Hoffmann, Fratti, Fridlender, Gagnon, Garin, Goldman, Gordon, Guermonprez, Guo, Gutierrez, Gutierrez, Harris, Harrison, He, Henault, Herweg, Hoffmann, Houde, Hoving, Huang, Husebye, Huynh, Jahraus, Jancic, Jeschke, Jung, Jutras, Kagan, Kagan, Kim, Kjeken, Lawe, Lennon-Duménil, Levin, Li, Li, Li, Luzio, Ma, Manoury, Mansour, Martinez, Martinez, Martinez, Matthias Trost, McDade, Mehta, Misch, Mouchess, Nair-Gupta, Naujoks, Nilsen, Nordenfelt, Pei, Peplowska, Pires, Pozzi, Ramachandra, Regnault, Reimann, Rink, Rogers, Romao, Roy, Rudi Beyaert, Rybicka, Sanjuan, Savina, Savina, Sepulveda, Smith, Smith, Steigbigel, Sturgill-Koszycki, Tan, Tobian, Touret, Trombetta, Trost, Trost, Underhill, Van der Wel, Via, Vieira, Wagner, Wetzel, Wollert, Yates, Yates, Yates, Yates   +122 more
core   +4 more sources

The extraordinary phagosome [PDF]

Nature, 2002
The finding that a cellular compartment called the endoplasmic reticulum can merge with the cell's outer membrane is surprising. It would not have been predicted from our knowledge of cell organization.
openaire   +1 more source

Rapid Clearance of Tetracapsuloides bryosalmonae Spores by Freshwater Sponge Ephydatia muelleri: Potential Implications for Controlling Proliferative Kidney Disease in Salmonids

Journal of Fish Diseases, EarlyView.
ABSTRACT Host–parasite interactions are influenced by both abiotic and biotic factors. While abiotic drivers, particularly temperature, have received considerable attention in recent years due to global climate change, the role of biotic factors remains comparatively underexplored.
Lauri Saks, Lilian Pukk, Siim Kahar, Magnus Lauringson, Anti Vasemägi   +4 more
wiley   +1 more source

Supporting Cells Remove and Replace Sensory Receptor Hair Cells in a Balance Organ of Adult Mice [PDF]

, 2017
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates.
Bucks, Stephanie A, Cox, Brandon C, Manning, James P, Nguyen, Tot B, Stone, Jennifer S, Vlosich, Brittany A   +5 more
core   +1 more source