Results 51 to 60 of about 9,767 (219)

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class [PDF]

, 2016
New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) including alpha-methyl tryptamines (AMTs), dimethyl ...
Brandt, SD, Dinger, J, Maurer, HH, Meyer, MR, Woods, C   +4 more
core   +1 more source

Photocatalytic Reduction of Nitroaromatic Compounds Using NiO‐Modified MgAl Hydrotalcite: A Sustainable Approach for Wastewater Treatment

Journal of Chemistry, Volume 2026, Issue 1, 2026.
The growing industrialization has caused the generation of highly toxic compounds such as nitroaromatic compounds. An adequate treatment to reduce the contamination of these organic compounds is necessary. The photocatalytic reduction of aromatic compounds using semiconductor materials favors the production of nitroaromatics.
Leimmy Calderon, Daniela Barrera, Claudia Castañeda, Jose J. Martínez, Hugo Rojas, Francisco Tzompanzi, Dora Solis, Sonia Mancipe Estevez, Munmun Bardhan   +8 more
wiley   +1 more source

Obituary to analgesic nephropathy—an autopsy study [PDF]

, 2017
Background. To determine whether classic analgesic nephropathy with renal papillary and urothelial capillary sclerosis could still be detected at autopsy in the beginning of the 21st century, the present study which is similar to a previous one performed
Brunner, Felix P., Khanlari, Bettina, Mihatsch, Michael J.   +2 more
core  

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

ChemistryOpen, Volume 14, Issue 12, December 2025.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder, Mostafa E. Salem, Saied M. Soliman, Ismail A. Elhaty, Naglaa S. Mahmoud, Mohamed Abdel‐Megid, Kamal M. Dawood   +6 more
wiley   +1 more source

Non-phenacetin analgesics and analgesic nephropathy: Clinical assessment of high users from a case-control study [1]* [PDF]

, 2017
Background. A recent large-scale case-control study on analgesic nephropathy (SAN) [1] found no increased risk of end-stage renal disease (ESRD) in users of combined or single formulations of phenacetin-free analgesics.
Graf, Helmut, Heinemann, Lothar, Koch, Karl-Martin, Michielsen, Paul, Mihatsch, Michael, Schnülle, Peter   +5 more
core  

Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies [PDF]

, 2018
An automated in-capillary assay requiring very small quantities of reagents was developed for performing in vitro cytochrome P450 (CYP450) drug metabolism studies. The approach is based on the following: (i) hydrodynamic introduction of nanoliter volumes
Curcio, R., Nicoli, R., Rudaz, S., Veuthey, J.-L   +3 more
core  

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

Frontiers in Pharmacology, 2022
Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in ...
Yawen Yuan, Yawen Yuan, Qingfeng He, Shunguo Zhang, Min Li, Zhijia Tang, Xiao Zhu, Zheng Jiao, Weimin Cai, Xiaoqiang Xiang   +9 more
doaj   +1 more source

Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross‐sectional Study

Brain and Behavior, Volume 15, Issue 11, November 2025.
Systemic inflammation indices (SII, SIRI, and AISI) were linked to clinical phenotypes in medication overuse headache (MOH). Specifically, higher SII and AISI showed independent associations with MOH. ABSTRACT Background The role of peripheral inflammation in medication overuse headache (MOH) remains inadequately understood.
Changling Li, Peiqi He, Mengmeng Ma, Yanbo Li, Jinghuan Fang, Qian Liu, Yang Zhang, Xin Jiang, Shiqin Li, Hui Lang, Ning Chen, Li He   +11 more
wiley   +1 more source

Molecular Modeling of Cytochrome P450 1A1 using the newly Crystallized Template structure of CYP1A2-Human

NUST Journal of Natural Sciences, 2021
Cytochrome P450 enzyme family plays significant roles in carcinogenesis and xenobiotic detoxification. CYP1A1 is the P450 family 1 enzyme preferably expressed extrahepatically and participates extensively in monooxygenase activity which can either ...
Rehan Zafar, Fahed Parvaiz, Babar Aslam, Umar Niazi   +3 more
doaj   +1 more source

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source