Results 51 to 60 of about 477,836 (336)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Antioxidant Capacity Of Frangipani (Plumeria Alba) Powder Extract [PDF]

, 2011
This research aimed to identify the antioxidant capacity, vitamin C (ascorbic acid), and total phenolic compounds of frangipani flower powder. The powder was extracted using ethanol, methanol, acetic acid, and water (aquadest).
Bagiada, N. A. (Nyoman), Mantik Astawa, I Nyoman, Wirawan, I. G. (I), Wrasiati, L. P. (Luh)   +3 more
core  

Biologically active compounds from selected aphyllophorales mycelial cultures [PDF]

, 2014
The obtained results confirm the hypothesis that mycelial cultures of domestic species of aphyllophorales are able to accumulate biologically active metabolites.Uzyskane wyniki wskazują, że przebadane kultury mycelialne krajowych gatunków grzybów ...
Firlej, Anna, Muszyńska, Bożena, Sułkowska-Ziaja, Katarzyna   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Changes in phenolic content, composition, and antioxidant activity of blood oranges during cold and on-tree storage

Journal of Integrative Agriculture, 2022
Citrus fruits are rich in phenolic compounds that possess several health benefits. However, few studies have focused on the changes in phenolic compounds in citrus fruits during postharvest storage.
Ji-chun ZHAO, Miao AO, Xiao-qin HE, Wei-zhou LI, Li-li DENG, Kai-fang ZENG, Jian MING   +6 more
doaj   +1 more source

Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]

, 2015
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa, Florêncio Nogueira, Fouzi Mouffouk, Hugo Pereira, José Manuel, João Varela, Khalid M. Abu-salah, Luísa Barreira, Luísa Custódio, Maria João Rodrigues, Marta Oliveira, Nuno Da Rosa Neng, Radhouan Ben-hamadou, Salman A. Alrokayan, The Red Sea   +14 more
core   +4 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Characterization of Soaking Process’ Impact in Common Beans Phenolic Composition: Contribute from the Unexplored Portuguese Germplasm

Foods, 2019
Despite the common beans’ nutritional and phytochemical value, in Portugal its consumption decreased more than 50% in the last decade. The present study aimed to characterize phenolic composition of the Portuguese traditional varieties and ...
Elsa Mecha, Susana T. Leitão, Bruna Carbas, Ana T. Serra, Pedro M. Moreira, Maria Manuela Veloso, Ricardo Gomes, Maria E. Figueira, Carla Brites, Maria C. Vaz Patto, Maria R. Bronze   +10 more
doaj   +1 more source

HPLC-DAD-qTOF Compositional Analysis of the Phenolic Compounds Present in Crude Tomato Protein Extracts Derived from Food Processing

Molecules, 2021
The conversion of raw fruits and vegetables, including tomatoes into processed food products creates side streams of residues that can place a burden on the environment.
Ana Miklavčič Višnjevec, Paul W. Baker, Kelly Peeters, Matthew Schwarzkopf, Dominik Krienke, Adam Charlton   +5 more
doaj   +1 more source

Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study [PDF]

, 2015
Background: Olive oil (OO) consumption is associated with cardiovascular disease prevention because of both its oleic acid and phenolic contents. The capacity of OO phenolics to protect against low-density lipoprotein (LDL) oxidation is the basis for a ...
Altman, American Diabetes Association, Ayse Karadag, Benzie, Brookes, Carrasco-Pancorbo, Charles, Coon, Covas, Covas, Dakna, Delles, Emilie Combet, Farràs, Favati, Fitó, Fliser, Friedewald, Harald Mischak, Hollman, Julian, Justina Siwy, Kontogianni, Kroke, Lawes, Lee, Levi, Lopez-Miranda, Maahs, Maria E Figueira, Maria R Bronze, Martín-Peláez, Mischak, Mullen, Owen, Reaven, Rossi Sa, Sandra Silva, Snell-Bergeon, Sofi, Theodorescu, Tripoli, Tunstall-Pedoe, Urpi-Sarda, Vlassopoulos, Vlassopoulos, William Mullen, Zimmerli   +47 more
core   +1 more source