Results 61 to 70 of about 462,769 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Phenolic compounds as vegetables' autoprotection

open access: yesGrasas y Aceites, 1993
This article covers the studies on phytoalexins activity of phenolic compounds (cinnamic acids, flavonoids, isoflavonoids, deoxianthocyanins, stilbenes, coumarins, chromones) against fungi and bacteria.
R. Maestro-Durán   +2 more
doaj   +1 more source

Beneficial effects of phenolic compounds: native phenolic compounds vs metabolites and catabolites

open access: yesCritical Reviews in Food Science and Nutrition, 2023
In the human body, the positive effects of phenolic compounds are increasingly observed through their presence in tissues and organs in their native form or in the form of metabolites or catabolites formed during digestion, microbial metabolism, and host biotransformation. The full extent of these effects is still unclear.
Lidija, Jakobek, Christopher, Blesso
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

The Effect of Rootstocks on the Peel Phenolic Compounds of Clementine Mandarin (Citrus clementina) [PDF]

open access: yesJournal of Medicinal Plants and By-products, 2017
Studies have shown that phenolic compounds are important in human health.The purpose of this research was to examine the influence of rootstocks on phenolic compounds. The content of individual phenolic compounds in fruits was determined by HPLC.
Behzad Babazadeh Darjazi, Kamkar Jaimand
doaj  

Plant Biomarker Pattern, Screening Programme for Phytochemical Differences in Plants Exposed to Stress [PDF]

open access: yes, 2002
A screening programme is developed to investigate phytochemical differences in plants xposed to stress compared with non-exposed plants. The screening programme, in its resent form or in a more simplified form, can be utilized in several different areas ...
Adsersen, Anne   +4 more
core  

Recovery of Polyphenols from Brewer’s Spent Grains [PDF]

open access: yes, 2019
peer-reviewedThe recovery of antioxidant polyphenols from light, dark and mix brewer’s spent grain (BSG) using conventional maceration, microwave and ultrasound assisted extraction was investigated.
Birsan, Rares   +3 more
core   +2 more sources

Anaerobic Degradation of Phenolic Compounds [PDF]

open access: yesNaturwissenschaften, 2000
Mononuclear aromatic compounds are degraded anaerobically through three main pathways, the benzoyl-CoA pathway, the resorcinol pathway, and the phloroglucinol pathway. Various modification reactions channel a broad variety of mononuclear aromatics including aromatic hydrocarbons into either one of these three pathways.
Schink, Bernhard   +2 more
openaire   +3 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

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