Results 51 to 60 of about 270,358 (309)

Biological properties of phenolic compounds from industrial wastes [PDF]

open access: yes, 2017
Phenolic compounds are a large family of metabolites that result from the secondary metabolism of plants. Novel insights about phenolic chemical structure, analytical methods, therapeutic effects, sensory properties, viticultural practices to modify ...
Rodriguez Vaquero, Maria Jose   +1 more
core  

Phenolic compounds as vegetables' autoprotection

open access: yesGrasas y Aceites, 1993
This article covers the studies on phytoalexins activity of phenolic compounds (cinnamic acids, flavonoids, isoflavonoids, deoxianthocyanins, stilbenes, coumarins, chromones) against fungi and bacteria.
R. Maestro-Durán   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]

open access: yes, 2012
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
Allsopp Philip   +51 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Phenolic compounds from the stem bark of Saccopetalum horsfieldii Benn. [PDF]

open access: yes, 2015
Column chromatographic separation of the methanol extract from the Saccopatlumhorsfieldii Benn’sstem bark yielded four phenolic components including three flavonoids, kaempferol-3,4’-dimethylether(1), quercetin-3,7- dimethylether(2), quercetin-3,7,4 ...
Alfinda Novi Kristanti*, .-   +2 more
core  

Cereus peruvianus Mill. (Cactaceae) as a source of natural antioxidants: Phenolic compounds and antioxidant activity of cladode extracts in two collection periods

open access: yesCurrent Research in Food Science, 2022
The economic potential of the cactus species Cereus peruvianus Mill. (syn. C. hildmannianus K. Schum.) has already been demonstrated through the generation of products and patents.
Adrieli Rodrigues da Costa Nunes   +7 more
doaj   +1 more source

The Interaction of Phenolic Compounds With Bacteria

open access: yesJournal of Pharmacy and Pharmacology, 1959
Abstract The uptake of hexylresorcinol by suspensions of E. coli and the associated release of cellular constituents were examined using heat-killed and butanol-treated organisms. The effect of the addition of cetomacrogol to the system was evaluated in terms of the reduction in the extent of drug binding and the prevention of the ...
A H Beckett, S J Patki, Ann E Robinson
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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