Results 181 to 190 of about 8,013 (194)
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Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly
American Journal of Medical Genetics Part A, 2017Phosphoglycerate dehydrogenase (PHGDH) deficiency (OMIM 256520) is a rare autosomal recessive disorder of serine synthesis, with mostly severe congenital microcephaly, caused by mutations in the PHGDH gene. Fourteen patients reported to date show severe, early onset, drug resistant epilepsy.
Antoine Poli +12 more
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Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease
Cell Metabolism, 2022Recent work from Bonvento and colleagues indicated that synaptic and memory deficits in early Alzheimer's disease (AD) are related to a shortage in L-serine production in astrocytes. Here, the authors, responding to correspondence from Chen and colleagues, discuss how this deficiency does not necessarily require a decrease in PHGDH expression and ...
Bonvento, Gilles +2 more
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PHGDH amplification and altered glucose metabolism in human melanoma
Pigment Cell & Melanoma Research, 2011SummaryThe metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare.
Edouard, Mullarky +4 more
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PHGDH Inhibition Overcomes Glioblastoma Resistance to T-cell Therapy
Cancer Discovery, 2023Abstract Phosphoglycerate dehydrogenase (PHGDH) inhibition improves T-cell therapy efficacy in glioblastoma.
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A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism
European Journal of Medicinal Chemistry, 2021Emerging evidence suggests that cancer metabolism is closely associated to the serine biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is converted to serine through a three-step enzymatic transformation. As the rate-limiting enzyme in the first step of SSP, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in ...
Jia-Ying Zhao +7 more
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Increased Expression of PHGDH Under High-Selenium Stress In Vivo
Biological Trace Element ResearchThe purpose of this study is to explore the glycolytic remodeling under high-selenium (Se) stress. Three groups of male C57BL/6J mice were fed on diets with different Se contents (0.03, 0.15, and 0.30 mg Se/kg). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were measured at the third month. Mice were killed at the fourth month.
Qin, Wang +7 more
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An idle PHGDH takes control of cell fate
Cell Research, 2023Linchong Sun, Ping Gao
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PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism
Cell Death & DifferentiationImmune cells modify their metabolic pathways in response to fungal infections. Nevertheless, the biochemical underpinnings need to be better understood. This study reports that fungal infection drives a switch from glycolysis to the serine synthesis pathway (SSP) and one-carbon metabolism by inducing the interaction of spleen tyrosine kinase (SYK) and ...
Xinyong Zhang +10 more
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Insights from Natural Product PHGDH Inhibitor Studies
Journal of Cellular Signaling, 2022openaire +1 more source
Targeting PHGDH exerts anti-oncogenic effects in bladder cancer
European Urology Supplements, 2019H. Yoshino +5 more
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