The dltC gene contributes to polyhexamethylene biguanide resistance in Staphylococcus aureus [PDF]
Frontiers in MicrobiologyAs the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies.
Chenyang Guo +10 more
doaj +2 more sources
Polihexanide (PHMB) 0.08% versus currently used treatments for Acanthamoeba keratitis: indirect treatment comparisons [PDF]
BMJ Open OphthalmologyBackground/aims Acanthamoeba keratitis is a rare, severe corneal infection. Until the recent approval of polihexanide (PHMB) 0.08% by the European Medicines Agency, there were no licensed medical therapies and current treatments relied on off-label or ...
Vincenzo Papa +7 more
doaj +2 more sources
Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa +11 more
doaj +7 more sources
Bactericidal Effect and Mechanism of Polyhexamethylene Biguanide (PHMB) on Pathogenic Bacteria in Marine Aquaculture [PDF]
BiologyGuanidine disinfectants are cationic polymers recognized for their effective sterilization properties and their ability to prevent bacterial resistance.
Lanting Wu +9 more
doaj +2 more sources
Polyhexamethylene Biguanide Nanoparticles Inhibit Biofilm Formation by Mastitis-Causing Staphylococcus aureus [PDF]
Veterinary SciencesStaphylococcus aureus is a mastitis pathogen that compromises cow health and causes significant economic losses in the dairy industry. High antimicrobial resistance and biofilm formation by S. aureus limit the efficacy of conventional treatments.
Renata de Freitas Leite +9 more
doaj +2 more sources
Comparison of antimicrobial efficacy and therapeutic index properties for common wound cleansing solutions, focusing on solutions containing PHMB [PDF]
GMS Hygiene and Infection ControlBackground: Surgical site infections (SSIs) have been shown to increase patient morbidity and mortality, impact on quality of life and place a significant economic burden on healthcare systems worldwide.
Watson, Fergus +3 more
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Effect of polyhexamethylene biguanide-coated central venous catheters on bacterial colonization in cancer patients undergoing abdominal surgery: a randomized controlled trial [PDF]
Frontiers in MedicineBackgroundCentral venous catheters (CVCs) are widely used in critically ill patients, including cancer patients, but are associated with complications such as catheter-related bloodstream infections (CRBSIs).
Jun Dong +5 more
doaj +2 more sources
Membranes, 2022 Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB)
Baramee Chanabodeechalermrung +6 more
doaj +1 more source
JDS Communications, 2021 Postmilking teat disinfection is one of the main measures used to prevent mastitis caused by contagious pathogens, such as Staphylococcus aureus. The present study evaluated the antimicrobial activity of polyhexamethylene biguanide (PHMB) and PHMB ...
R.F. Leite +7 more
doaj +1 more source
Effect of combined therapy polyhexamethylene biguanide and Coriolus-MRL on human papilloma virus (HPV) cervical and vulvar-related lesions [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2020 OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation.
D. Gincheva, V. Gincheva, E. Konova
doaj +1 more source