Results 11 to 20 of about 4,025 (191)

The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes [PDF]

Scientific Reports, 2016
To combat infection and antimicrobial resistance, it is helpful to elucidate drug mechanism(s) of action. Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells.
A Gentile, B Spellberg, CE Barry, CR Messick, DJ Dwyer, EE Creppy, EF Palermo, FW O’Grady, G Muller, G Muller, G Rusciano, GS Gordon, J Portugal, JD McCool, JM Boberek, JP Armitage, L Good, LP O’Malley, M Mondhe, MA Kohanski, MJ Allen, MJ Allen, MJ Allen, N Nekhotiaeva, Nakashima, P Broxton, P Broxton, P Broxton, P Erbacher, P Gilbert, R de Vries, R Dryselius, R Firdessa, R Spurio, RF Murphy, S Amoils, S Goh, S Wessels, T Ikeda, T Ikeda, T Kornberg, VB Teif   +41 more
core   +7 more sources

Fungal cell barriers and organelles are disrupted by polyhexamethylene biguanide (PHMB)

Scientific Reports, 2023
The similarities between fungal and mammalian cells pose inherent challenges for the development of treatments for fungal infections, due to drug crossover recognition of host drug targets by antifungal agents.
Winnie Ntow-Boahene, Isabelle Papandronicou, Josephous Miculob, Liam Good   +3 more
doaj   +3 more sources

Polyhexanide (PHMB) – properties and applications in medicine

European Journal of Biological Research, 2020
Polyhexamethylene biguanide (PHMB) is one of the many antiseptics available in the medicine. It stands out from the others with its numerous advantages.
Patrycja Szkołuda, Tomasz M. Karpiński
doaj   +2 more sources

PHMB: Utilización del apósito de espuma antimicrobiana (AMD) KendallTM (PHMB 0,5%) en el tratamiento de las heridas crónicas [PDF]

Gerokomos, 2010
Abordamos la parte más problemática del tratamiento de las heridas crónicas o agudas, de acuerdo con los profesionales especializados es la infección de la herida.
John Timmons, Kathy Leak
doaj   +3 more sources

From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi-Hydrogenation. [PDF]

Angew Chem Int Ed Engl
We present a new catalytic process that converts real‐life PET waste into ethyl 4‐hydroxymethylbenzoate (EHMB), which serves as a valuable intermediate for the synthesis of pharmaceuticals, an insecticide, and a novel polyester. Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4 ...
Kulyabin PS, Luk J, Uslamin EA, Kolganov AA, Saini G, Marcial-Hernandez R, Pancholi K, Kühne B, Dauth A, McKay AP, Cordes DB, Pidko EA, Kumar A.   +12 more
europepmc   +3 more sources

Polyhexanide, Povidone-Iodine, and Hypochlorous Acid Show High In Vitro Antimicrobial Efficacy Against Pathogens Commonly Associated With Equine Infectious Keratitis. [PDF]

Vet Ophthalmol
ABSTRACT Objective To determine the in vitro antimicrobial activity of specific antiseptics against common equine ocular surface pathogens. Methods Staphylococcus aureus (S. aureus) (n = 12), Streptococcus equi subspecies zooepidemicus (S. zooepidemicus) (n = 9), Enterobacter hormaechei (E. hormaechei) (n = 6), and Bacillus cereus (B.
Stolle LM, Oltmanns H, Meißner J, Heun F, Schieder AK, Wolff HT, Ohnesorge B, Busse C.   +7 more
europepmc   +2 more sources

Pantoea agglomerans in Equine Ulcerative Keratitis: Prevalence and Comparative Efficacy of Four Topical Antiseptics. [PDF]

Vet Ophthalmol
ABSTRACT Objective To determine the minimal bactericidal concentration (MBC) and effective contact time of four topical antiseptics—polyhexanide, povidone‐iodine (PVP‐I), hypochlorous acid (HOCl), and N‐acetylcysteine (NAC)—against Pantoea agglomerans, a pathogen frequently isolated in equine ulcerative keratitis.
Heun F, Meißner J, Schieder AK, Ohnesorge B, Busse C.   +4 more
europepmc   +2 more sources

Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers [PDF]

PeerJ, 2018
Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack
Yassine Bouattour, Philip Chennell, Mathieu Wasiak, Mireille Jouannet, Valérie Sautou   +4 more
doaj   +2 more sources

Polyvinyl Alcohol/Chitosan/Polyhexamethylene Biguanide Phase Separation System: A Potential Topical Antibacterial Formulation with Enhanced Antimicrobial Effect

Molecules, 2020
An aqueous polyvinyl alcohol (PVA)/chitosan (CHT)/polyhexamethylene biguanide (PHMB) blends (PVA/CHT/PHMB blends) has been developed as a potential low dose topical antibacterial formulation with enhanced antimicrobial effect.
Yunzhou Ni, Zhixiang Qian, Yu Yin, Weien Yuan, Fei Wu, Tuo Jin   +5 more
doaj   +1 more source

Study of Epigenetic Properties of Poly(HexaMethylene Biguanide) Hydrochloride (PHMB) [PDF]

International Journal of Environmental Research and Public Health, 2014
Poly(HexaMethylene Biguanide) hydrochloride (PHMB) CAS No. [32289-58-0] is a particularly effective member of the biguanides antiseptic chemical group, and has been in use since the early fifties in numerous applications. It has been proposed that PHMB be classified as a category 3 carcinogen although PHMB is not genotoxic.
Creppy, Edmond E., Diallo, Aboudoulatif, Moukha, Serge, Eklu-Gadegbeku, Christophe, Cros, Daniel   +4 more
openaire   +5 more sources