Results 21 to 30 of about 3,896 (155)

[Acanthamoeba keratitis treated with propamidine and polyhexamethyl biguanide (PHMB)].

Revista medica de Chile, 2002
The diagnosis of acanthamoeba keratitis has increased since 1985 due to the massive use of contact lenses and a better knowledge of the disease by ophthalmologists. The use of biassociated therapy has resulted in a better prognosis and lower complication rate.To report patients with acanthamoeba keratitis treated with the association of propamidine ...
Rodrigo, Donoso, Juan José, Mura, Mauricio, López   +2 more
openaire   +4 more sources

The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08% (Polihexanide) and Placebo versus PHMB 0.02% and Propamidine 0.1.

Ophthalmology, 2023
To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml)+ propamidine 0.1% (1 mg/ml) with PHMB 0.08% (0.8 mg/ml)+ placebo (PHMB 0.08%) for Acanthamoeba keratitis (AK) treatment.Prospective, randomized, double-masked, active-controlled, multicenter phase 3 study (ClinicalTrials.gov identifier, NCT03274895).One hundred thirty-five patients treated at 6 ...
Dart, John K.G., Papa, Vincenzo, Rama, Paolo, Knutsson, Karl Anders, Ahmad, Saj, Hau, Scott, Sanchez, Sara, Franch, Antonella, Birattari, Federica, Leon, Pia, Fasolo, Adriano, Kominek, Ewa Mrukwa, Jadczyk-Sorek, Katarzyna, Carley, Fiona, Hossain, Parwez, Minassian, Darwin C.   +15 more
openaire   +4 more sources

Fungal cell barriers and organelles are disrupted by Polyhexamethylene biguanide (PHMB)

Scientific Reports, 2022
Abstract The similarities between fungal and mammalian cells pose inherent challenges for the development of treatments for fungal infections, due to drug crossover recognition of host drug targets by antifungal agents. Thus, there are a limited number of drug classes available for treatment.
Winnie Ntow-Boahene, Isabelle Papandronicou, Josephous Miculob, Liam Good   +3 more
openaire   +3 more sources

Effect of poly-hexamethylene biguanide hydrochloride (PHMB) treated non-sterile medical gloves upon the transmission of Streptococcus pyogenes, carbapenem-resistant E. coli, MRSA and Klebsiella pneumoniae from contact surfaces [PDF]

, 2017
BACKGROUND: Reduction of accidental contamination of the near-patient environment has potential to reduce acquisition of healthcare-associated infection(s).
Ali, S, Wilson, APR
core   +1 more source

Variable effects of exposure to formulated microbicides on antibiotic susceptibility in firmicutes and proteobacteria [PDF]

, 2016
Microbicides are broad-spectrum antimicrobial agents that generally interact with multiple pharmacological targets. While they are widely deployed in disinfectant, antiseptic, and preservative formulations, data relating to their potential to select for ...
Amézquita, Alejandro, Cowley, Nicola L., Drake, H. L., Forbes, Sarah, Humphreys, Gavin, Knight, Christopher G., McBain, Andrew J., McClure, Peter   +7 more
core   +1 more source

A Comprehensive Review of Clinical Studies on Bacterial Cellulose: From the Earliest Uses to Contemporary Innovations. [PDF]

Adv Healthc Mater
Bacterial cellulose has undergone a transformative journey from early applications to its role in advanced regenerative medicine. The review has a pedagogical ambition, offering clear pathways for future research and clinical adoption. Harmonizing regulatory standards and conducting larger, well‐designed clinical trials with standardized endpoints will
Meslier T, D'Antin JC, Julio G, Roig A.
europepmc   +2 more sources

Die Aufnahme von PHMB in epicitehydro(R)

, 2019
Einleitung: Die stetige Zunahme von Antibiotikaresistenzen ist besonders für VerbrennungspatientInnen relevant, da diese oft sehr große Wundflächen aufweisen und oft mit Wundinfektionen zu kämpfen haben. 43% der Verbrennungspezialisten aus der ganzen Welt sind sich einig, dass[zum vollständigen Text gelangen Sie über die oben angegebene URL]
Holzer, JCJ, Tuca, AC, Bernadelli de Mattos, I, Groeber-Becker, F, Funk, M, Popp, D, Mautner, S, Birngruber, T, Kamolz, LP   +8 more
openaire   +1 more source

A Systematic Comparison of Antimicrobial Wound Dressings using a Planktonic Cell and an Immobilised Cell Model. Kamran [PDF]

, 2015
Aim: The aim of the study was to evaluate the ability of in-vitro planktonic and immobilised cell models for determining the antimicrobial efficacy of common antimicrobial wound dressings.
Abdelrahman, Agren, Alandejani, Asavavisithchai, Barrett, Brackman, Brackman, Bradshaw, BSI, BSI, BSI, Castellano, Chopra, Donlan, Durante, Eberlein, Fong, French, Gallant-Behm, Herruzo, Hill, Ip, Kucera, Lindsay, Lu, Merckoll, Moore, Mullai, O'Shea, Olaitan, Ovington, Parsons, Rasmussen, Sebeny, Stephen-Haynes, Thomas, Thorn, Tkachenko, Toit, Turton, White, Wild   +41 more
core   +2 more sources

Effects of formulation on microbicide potency and mitigation of the development of bacterial insusceptibility [PDF]

, 2015
Risk assessments of the potential for microbicides to select for reduced bacterial susceptibility have been based largely on data generated through the exposure of bacteria to microbicides in aqueous solution.
Amézquita, Alejandro, Cowley, Nicola L., Drake, H. L., Forbes, Sarah, Humphreys, Gavin J., McBain, Andrew J., McClure, Peter   +6 more
core   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source