Results 11 to 20 of about 405,250 (376)

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells*

Journal of Biological Chemistry, 2000
3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K signaling controls the macroautophagic pathway (Blommaart, E. F.
A. Petiot, E. Ogier-Denis, E. Blommaart, A. Meijer, P. Codogno   +4 more
semanticscholar   +1 more source

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica

Frontiers in Cellular and Infection Microbiology, 2019
Phosphatidylinositol (PtdIns) metabolism is indispensable in eukaryotes. Phosphoinositides (PIs) are phosphorylated derivatives of PtdIns and consist of seven species generated by reversible phosphorylation of the inositol moieties at the positions 3, 4,
Kumiko Nakada-Tsukui, Natsuki Watanabe, Natsuki Watanabe, Tomohiko Maehama, Tomoyoshi Nozaki   +4 more
doaj   +1 more source

PI(3,4)P2 Signaling in Cancer and Metabolism

Frontiers in Oncology, 2020
The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer metabolism, and cancer cell proliferation.
Luca Gozzelino, Maria Chiara De Santis, Federico Gulluni, Emilio Hirsch, Miriam Martini   +4 more
doaj   +1 more source

Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway [PDF]

International Neurourology Journal, 2014
PurposeBerberine is a type of isoquinoline alkaloid that has been used to treat various diseases. A neuroprotective effect of berberine against cerebral ischemia has been reported; however, the effects of berberine on apoptosis in relation to reactive ...
Mia Kim, Mal Soon Shin, Jae Min Lee, Han Sam Cho, Chang Ju Kim, Young Joon Kim, Hey Ran Choi, Jung Won Jeon   +7 more
doaj   +1 more source

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

Journal of Cell Biology, 2001
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturation is unknown. Using chimeric fluorescent proteins encoding
Otília V. Vieira, R. Botelho, L. Rameh, S. Brachmann, T. Matsuo, H. Davidson, A. Schreiber, J. Backer, L. Cantley, S. Grinstein   +9 more
semanticscholar   +1 more source

Molecular Docking and Molecular Dynamics Simulation Studies of Quinoline-3-Carboxamide Derivatives with DDR Kinases–Selectivity Studies towards ATM Kinase

Chemistry, 2021
Quinoline-3-carboxamides are an essential class of drug-like small molecules that are known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases.
Srimadhavi Ravi, Bhanu Priya, Pankaj Dubey, Vijay Thiruvenkatam, Sivapriya Kirubakaran   +4 more
doaj   +1 more source

Calmodulin Activates Phosphatidylinositol 3-Kinase [PDF]

Journal of Biological Chemistry, 1997
Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector protein, regulates multiple processes in eukaryotic cells, including cytoskeletal organization, vesicular trafficking, and mitogenesis.
J L, Joyal, D J, Burks, S, Pons, W F, Matter, C J, Vlahos, M F, White, D B, Sacks   +6 more
openaire   +2 more sources

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]

, 2010
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt, Benjamin T Houseman, Christian Rommel, Daniel D Le, Fabrice Gorrec, Jeffrey P Shaw, Joseph I Pacold, Kevan M Shokat, Matthias K Schwarz, Olusegun Williams, Pascale Gaillard, Pingda Ren, Roger L Williams, Simon Miller, Thomas Rückle, Wai-Ching Hon, Yi Liu   +16 more
core   +2 more sources

PI3K pathway in NSCLC

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3’-hydroxyl group of phosphatidylinositol and phosphoinositides.
Alex eMartínez Martí, Enriqueta eFelip
doaj   +1 more source