Results 201 to 210 of about 19,012 (341)

Sequential actions of phosphatidylinositol phosphates regulate phagosome-lysosome fusion. [PDF]

Mol Biol Cell, 2018
Jeschke A, Haas A.
europepmc   +1 more source

The Activation Loop of Phosphatidylinositol Phosphate Kinases Determines Signaling Specificity [PDF]

, 2000
Jeannette Kunz, Monita P. Wilson, Marina V. Kisseleva, James H. Hurley, Philip W. Majerus, Richard A. Anderson   +5 more
openalex   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Type I Phosphatidylinositol 4-Phosphate 5-Kinase Directly Interacts with ADP-ribosylation Factor 1 and Is Responsible for Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Golgi Compartment [PDF]

, 2000
David H. Jones, James B. Morris, Clive P. Morgan, Hisatake Kondo, Robin F. Irvine, Shamshad Cockcroft   +5 more
openalex   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Lipid signalling in plant development and responses to environmental stresses

Frontiers in Plant Science, 2016
Eric eRuelland, Eric eRuelland, Olga eValentova   +2 more
doaj   +1 more source

Phosphatidylinositol 4-Phosphate 5-Kinase Its3 and Calcineurin Ppb1 Coordinately Regulate Cytokinesis in Fission Yeast [PDF]

, 2000
Yingjie Zhang, Reiko Sugiura, Yabin Lü, Masako Asami, Takuya Maeda, Toshiki Itoh, Tadaomi Takenawa, Hisato Shuntoh, Takayoshi Kuno   +8 more
openalex   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion. [PDF]

Sci Rep, 2015
Hirst DJ, Lee TH, Pattenden LK, Thomas WG, Aguilar MI.   +4 more
europepmc   +1 more source

Stimulation of Phosphatidylinositol-4-phosphate 5-Kinase by Rho-Kinase [PDF]

, 2000
Paschal A. Oude Weernink, Peter Caspar Schulte, Yuanjian Guo, Julia Wetzel, Mutsuki Amano, Kozo Kaibuchi, Sven Haverland, Matthias Voß, Martina Schmidt, Georg W. Mayr, Karl H. Jakobs   +10 more
openalex   +1 more source