Results 201 to 210 of about 13,924 (256)

Structural pathway for PI3-kinase regulation by VPS15 in autophagy. [PDF]

Science
Cook ASI, Chen M, Nguyen TN, Cabezudo AC, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH.   +12 more
europepmc   +1 more source

Phosphatidylinositol-3-phosphate mediates Arc capsid secretion through the multivesicular body pathway

Kritika Mehta, Henry Yentsch, J. Lee, Yeeun Yook, Kwan Young Lee, Tianyu Terry Gao, Nien‐Pei Tsai, Kai Zhang   +7 more
openalex   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Optimizing PH Domain-Based Biosensors for Improved Plasma Membrane PIP₃ Measurements in Mammalian Cells. [PDF]

Cells
Damouni A, Tóth DJ, Schönek A, Kasbary A, Boros AP, Várnai P.   +5 more
europepmc   +1 more source

Comparative lipidomic and proteomic analysis reveals species‐specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris

Pest Management Science, Volume 82, Issue 2, Page 1540-1551, February 2026.
Lipidomic and proteomic analysis revealed large‐scale differences in the midgut composition of the honeybee Apis mellifera and the buff‐tailed bumblebee Bombus terrestris. These differences correlated to increased insecticide absorption in the bumblebee when using an ex vivo Ussing chamber and subsequently in vivo feeding assay (created in Biorender ...
Emmanouil Kokkas, Joseph Hawkins, Lauraine Swindale, Aniko Kende, John Sinclair, Jacob M Riveron, Helen Thompson, Adam Pym   +7 more
wiley   +1 more source

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders. [PDF]

Biomolecules
Onu CJ, Adu M, Chakkour M, Kumar V, Greenberg ML.   +4 more
europepmc   +1 more source

The formation of inositol 1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. Evidence for direct phosphodiesteratic cleavage of phosphatidylinositol.

, 1985
J F Dixon, L E Hokin
openalex   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

The poly(A) polymerase Star-PAP is regulated by stably associated phosphoinositide messengers. [PDF]

J Biol Chem
Wen T, Chen M, Cryns VL, Anderson RA.
europepmc   +1 more source

Eps15 Homology Domain 1-associated Tubules Contain Phosphatidylinositol-4-Phosphate and Phosphatidylinositol-(4,5)-Bisphosphate and Are Required for Efficient Recycling

, 2009
Marko Jović, Fabien Kieken, Naava Naslavsky, Paul L. Sorgen, Steve Caplan   +4 more
openalex   +1 more source