Results 21 to 30 of about 12,824 (233)

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

Cell Reports, 2014
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A. Sehon, Robert W. Marquis, John Bertin, Peter J. Gough, Savvas Savvides, Jean-Claude Martinou, Mathieu J.M. Bertrand, Peter Vandenabeele   +15 more
doaj   +1 more source

Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate [PDF]

Journal of Biological Chemistry, 1998
Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have been shown to exist in cells.
K F, Tolias, L E, Rameh, H, Ishihara, Y, Shibasaki, J, Chen, G D, Prestwich, L C, Cantley, C L, Carpenter   +7 more
openaire   +2 more sources

An emerging role for PI5P in T cell biology

Frontiers in Immunology, 2013
Phosphoinositides are critical regulators in cell biology. Phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2, was the first variety of phosphoinositide to enter in the T cell signaling scene.
Jacques A Nunes, Jacques A Nunes, Jacques A Nunes, Jacques A Nunes, Geoffrey eGuittard   +4 more
doaj   +1 more source

Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. [PDF]

PLoS ONE, 2012
BACKGROUND: Pleckstrin homology (PH) domains are common membrane-targeting modules and their best characterized ligands are a set of important signaling lipids that include phosphatidylinositol phosphates (PtdInsPs). PH domains recognize PtdInsPs through
Kanchan Anand, Kenji Maeda, Anne-Claude Gavin   +2 more
doaj   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

Natural Product Reports, 2007
This review highlights inositol polyphosphate- and phosphatidylinositol-based small molecule probes that have advanced our understanding of intracellular signalling.
Conway, Stuart J., Miller, Gavin J.
openaire   +4 more sources

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Nature Communications, 2019
Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from ...
Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu, Zhipu Luo, Li Yu, Andrew J. Brown, Hongyuan Yang, Jia-Wei Wu   +11 more
doaj   +1 more source

Evidence for a specific phosphatidylinositol 4-phosphate phosphatase in human erythrocyte membranes.

Journal of Lipid Research, 1984
Human erythrocyte membranes exhibit a specific phosphatidylinositol 4-phosphate phosphohydrolase (PtdIns4P phosphatase) activity which hydrolyzes PtdIns4P and lysoPtdIns4P but not phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) or lysoPtdIns(4,5)P2.
S E Mack, F B Palmer
doaj   +1 more source

The phosphatidylinositol 3‐phosphate‐binding FYVE finger [PDF]

FEBS Letters, 2002
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3‐phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P‐containing ...
Stenmark, Harald, Aasland, Rein, Driscoll, Paul C.   +2 more
openaire   +2 more sources

The analysis of tissue phospholipids: hydrolysis procedure and results with pig liver

Journal of Lipid Research, 1960
A procedure for the hydrolysis of phospholipids is described. The effect of alkali concentration, organic solvents, and length of hydrolysis have been studied. The initial reaction in the preferred solvent system appears to be a methanolysis.
G. Hübscher, J.N. Hawthorne, P. Kemp
doaj   +1 more source