Results 21 to 30 of about 19,012 (341)
Myoinositol in Autoimmune Thyroiditis
Frontiers in Endocrinology, 2022 Myoinositol (Myo) is an isoform of inositol, a cyclic polyol with 6 hydroxyl groups. Myo is mainly derived from dietary intake while its endogenous production is generated from glucose by enzymatic reactions.
Sabrina Rosaria Paparo +12 more
doaj +1 more source
Regulation of autophagy by phosphatidylinositol 3‐phosphate [PDF]
FEBS Letters, 2010 The simple phosphoinositide phosphatidylinositol 3‐phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events.
Nicholas T. Ktistakis, Chloe Burman
openaire +3 more sources
Membrane Phospholipids and Polyphosphates as Cofactors and Binding Molecules of SERPINA12 (vaspin)
Molecules, 2020 Visceral adipose tissue derived serine protease inhibitor (vaspin) is a member of the serpin family and has been shown to have beneficial effects on glucose tolerance, insulin stability as well as adipose tissue inflammation, parameters seriously ...
Catherine A. Tindall +6 more
doaj +1 more source
Regulation of CK2 Activity by Phosphatidylinositol Phosphates [PDF]
Journal of Biological Chemistry, 2005 The process of clathrin-coated vesicle (CCV) formation/disassembly involves numerous proteins that act cooperatively. Phosphorylation is an important regulatory mechanism governing protein interactions in CCVs, and many of the core and accessory proteins of the CCV machinery are reversibly phosphorylated in vivo.
Korolchuk, VI, Cozier, G, Banting, G
openaire +3 more sources
Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]
ACS Applied Materials & Interfaces Manuscript ID:
am-2021-004953.R2, 2021 Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv +1 more source
Frontiers in Microbiology, 2021 Flavivirus replication occurs in membranous replication compartments, also known as replication organelles (ROs) derived from the host ER membrane. Our previous study showed that the non-structural (NS) protein 1 (NS1) is the essential factor for RO ...
Yali Ci +8 more
doaj +1 more source
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
doaj +1 more source
Recent advances in expanding the coverage of the lipidome [PDF]
, 2017 The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators.
Kamphorst, Jurre J., Tumanov, Sergey
core +1 more source
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]
, 2010 Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt +16 more
core +2 more sources
An emerging role for PI5P in T cell biology
Frontiers in Immunology, 2013 Phosphoinositides are critical regulators in cell biology. Phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2, was the first variety of phosphoinositide to enter in the T cell signaling scene.
Jacques A Nunes +4 more
doaj +1 more source