Results 231 to 240 of about 73,519 (304)

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Platelet Apoptosis in Patients with Coronary Artery Disease Before and After CABG. [PDF]

Int J Mol Sci
Metelkin AA, Sergeeva EA, Popov MA, Zybin DI, Shumakov DV, Morozov SG, Sokolovskaya AA.   +6 more
europepmc   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Membrane potential modulates ERK activity and cell proliferation in human cells. [PDF]

Elife
Sasaki M, Nakahara M, Hashiguchi T, Ono F.   +3 more
europepmc   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Isoxazole Derivative Induces Apoptosis-like Death and Autophagy through Oxidative Stress in <i>Leishmania amazonensis</i>. [PDF]

ACS Omega
Kawano Bakoshi AB, Beltrame Machado RR, Pianoski KE, Mendes De Souza Melo S, Andreia Rosa F, Silva Lautenschlager SO, Ueda-Nakamura T, Nakamura CV, Lazarin-Bidóia D.   +8 more
europepmc   +1 more source

Spatial Regulation of Silicon Accumulation in Peduncle Confers Sheathed Spike in Barley

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4766-4779, August 2026.
ABSTRACT Peduncle, the uppermost internode in cereals, connects the stem to the inflorescence and is critical for the transport of water, nutrients and photosynthetic assimilates. While peduncle length associates with plant height and its elongation is primarily regulated by phytohormones, we report a previously unrecognized mechanism involving the ...
Wenxue Wu, Congcong Jiang, Guangqi Gao, Namiki Mitani‐Ueno, Yu Guo, Jinhong Kan, Yehui Xiong, Martin Mascher, Zhongfu Ni, Jian Feng Ma, Ke Wang, Ping Yang   +11 more
wiley   +1 more source

PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways. [PDF]

EBioMedicine
Gu W, Wan R, Chen Z, Wang W, Xie S, Hao C, Liu G, Wan M, Gao P.   +8 more
europepmc   +1 more source

Genomic and Physiological Insights Into Heat–Drought Tolerance in Wheat Through GWAS and Phenotypic Evaluation

Plant, Cell &Environment, Volume 49, Issue 8, Page 5511-5529, August 2026.
ABSTRACT Climate change‐driven heat and drought stresses during reproductive stages significantly threaten wheat productivity. To investigate the genetic and physiological basis of combined heat–drought (HD) tolerance, we evaluated 345 wheat genotypes under three environments of HD stresses, non‐stress glasshouse conditions and a late‐sowing field ...
Jingjuan Zhang, Weinan Xu, Rakshith S. R. Gowda, Joel Johnstone, Malona Alinsug, Abhishek Bohra, Vanika Garg, Annapurna Chitikineni, Dion Bennett, Meixue Zhou, Meiqin Lu, Chengdao Li, Zhong‐Hua Chen, Reyazul Rouf Mir, Rajeev K. Varshney   +14 more
wiley   +1 more source

Phosphatidylserine exposure and plasma membrane perforation as ferroptotic signatures for in vivo imaging. [PDF]

Npj Imaging
Sonay AY, Apfelbaum E, Larney BEM, Grimm J.   +3 more
europepmc   +1 more source