Results 211 to 220 of about 110,140 (293)

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

<i>In vitro</i> studies to investigate the potential neuroprotective and neurotransmitter modulation effects of a standardized <i>Ginkgo biloba</i> extract associated with phosphatidylserine. [PDF]

Front Nutr
Kara M, Hasbal-Celikok G, Gómez-Serranillos P, Gómez-Serranillos MS, Owsianik C, Yilmaz-Ozden T, Öztas E, Arda N, Tunc M, Sevim Ç, Petrangolini G, Rabbani F, Ujjan I, Khan A.   +13 more
europepmc   +1 more source

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

MedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Qin Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao   +8 more
wiley   +1 more source

Platelet Apoptosis in Patients with Coronary Artery Disease Before and After CABG. [PDF]

Int J Mol Sci
Metelkin AA, Sergeeva EA, Popov MA, Zybin DI, Shumakov DV, Morozov SG, Sokolovskaya AA.   +6 more
europepmc   +1 more source

Isoxazole Derivative Induces Apoptosis-like Death and Autophagy through Oxidative Stress in <i>Leishmania amazonensis</i>. [PDF]

ACS Omega
Kawano Bakoshi AB, Beltrame Machado RR, Pianoski KE, Mendes De Souza Melo S, Andreia Rosa F, Silva Lautenschlager SO, Ueda-Nakamura T, Nakamura CV, Lazarin-Bidóia D.   +8 more
europepmc   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Membrane potential modulates ERK activity and cell proliferation in human cells. [PDF]

Elife
Sasaki M, Nakahara M, Hashiguchi T, Ono F.   +3 more
europepmc   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways. [PDF]

EBioMedicine
Gu W, Wan R, Chen Z, Wang W, Xie S, Hao C, Liu G, Wan M, Gao P.   +8 more
europepmc   +1 more source

PPT1‐mediated plastidic phosphoenolpyruvate import enhances fatty acid biosynthesis in sugar‐rich tissues

New Phytologist, Volume 250, Issue 6, Page 3900-3913, June 2026.
Summary Metabolic engineering of vegetative tissues for lipid production holds transformative potential for sustainable biofuels, yet achieving sufficient yields remains challenging. Here, we present a strategy to enhance fatty acid synthesis by redirecting cytosolic phosphoenolpyruvate (PEP) into plastids through overexpression of the plastidial ...
Jiang Wang, Yi‐Hsuan Lin, Xueyi Xue, Gabriel Beuchat, Yaxin Li, Jiankun Li, Li‐Qing Chen   +6 more
wiley   +1 more source