Results 221 to 230 of about 78,278 (294)

RAP1-RHO small GTPase cross-talk mediates integrindependent and -independent platelet procoagulant response. [PDF]

Haematologica
Ballard-Kordeliski A, Ziegmann N, Schug W, Ginsberg MH, Schaefer A, Lee RH, Bergmeier W.   +6 more
europepmc   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Exogenous phosphatidylserine protects against mesenteric ischemia-reperfusion with associated Akt/mTOR pathway upregulation. [PDF]

Sci Rep
Hamaneh AM, Ghasemi M, Mehrabi MM, Ashtari S, Nejati F, Kazemzadeh H, Goudarzi R, Tavangar SM, Dehpour AR, Partoazar A.   +9 more
europepmc   +1 more source

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source

Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers. [PDF]

Front Immunol
Wu Y, Yang Z, Huang S, Bao J, Fan Y, Xie G.   +5 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Correction: MUS81 participates in the progression of serous ovarian cancer associated with dysfunctional DNA repair system. [PDF]

Front Oncol
Lu R, Xie S, Wang Y, Zheng H, Zhang H, Deng M, Shi W, Zhong A, Chen M, Zhang M, Xu X, Shammas MA, Guo L.   +12 more
europepmc   +1 more source

A Blood‐Derived Double‐Network Hydrogel with Robust Wet Adhesion for Keratinized Mucosa Regeneration via Neutrophil Phenotype Reprogramming and Mechanophysical Niche Modulation

Advanced Science, Volume 13, Issue 51, 14 September 2026.
The iPRF‐MA/Alg‐NHS/Lut@EGCG (PGAE) double‐network hydrogel achieves durable wet adhesion in the oral environment. It simultaneously reprograms neutrophils from NETosis to phagocytosis for biofilm clearance, and activates the FAK‐RhoA‐YAP mechanotransduction pathway in gingival fibroblasts to drive extracellular matrix remodeling, thereby promoting ...
Sicong Ren, Xinting Yang, Jingxia Chen, Yihan Wang, Jian Feng, Jing Zhou, Jiaxin Luo, Jingjie Zhai, Quan Lin, Yanmin Zhou   +9 more
wiley   +1 more source

The K247 ubiquitination site of the Newcastle disease virus M protein enhances viral budding to facilitate rapid exploitation of host cell sphingolipid metabolites. [PDF]

Poult Sci
Dai J, Liu F, Feng Y, You Q, Wang J, Ding C, Qiu X, Xiao S.   +7 more
europepmc   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source