Results 141 to 150 of about 47,423 (289)

Meta-analysis examining phosphodiesterase-5 inhibitors in heart failure with preserved ejection fraction. [PDF]

Proc (Bayl Univ Med Cent), 2022
Adhikari G, Baral N, Rauniyar R, Tse G, Karki S, Abdelazeem B, Gergis K, Savarapu P, Isa S, Sud P, Kunadi A.   +10 more
europepmc   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

8-Aryl xanthines potent inhibitors of phosphodiesterase 5

, 2002
Ruth Arnold, David Beer, Gurdip Bhalay, Urs Baettig, Stephen P. Collingwood, Sarah Craig, Nicholas Devereux, Andrew R. Dunstan, Angela Glen, Sylvie Gomez, Sandra Haberthuer, Trevor Howe, Stephen Jelfs, Heinz E. Moser, Reto Naef, Paul Nicklin, David A. Sandham, Rowan Stringer, Katharine L. Turner, Simon J. Watson, Mauro Zurini   +20 more
openalex   +1 more source

Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes [PDF]

, 2005
Gook Jun Ahn, Jae Young Yu, Seul Min Choi, Kyung Koo Kang, Byoung Ok Ahn, Jong Won Kwon, Sung Keun Kang, Byeong Chun Lee, Woo Suk Hwang   +8 more
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

A 10,000-Foot View at Survival and Treatment with Phosphodiesterase-5 Inhibitors in Interstitial Lung Disease Pulmonary Hypertension. [PDF]

Am J Respir Crit Care Med
Shlobin OA, Piccari L.
europepmc   +1 more source

Post-Implant Phosphodiesterase-5 Inhibitors in Patients with Left Ventricular Assist Device: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med, 2022
Xanthopoulos A, Magouliotis DE, Tryposkiadis K, Zotos PA, Spiliopoulos K, Athanasiou T, Giamouzis G, Skoularigis J, Starling RC, Triposkiadis F.   +9 more
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Efficacy and Safety of Phosphodiesterase-5 Inhibitors for Erectile Dysfunction in Schizophrenia: A Systematic Review and Meta-Analysis. [PDF]

Neuropsychiatr Dis Treat
Saito A, Sakuma K, Iwata N, Kishi T.
europepmc   +1 more source

Contemporary cost-analysis comparison of direct-to-consumer vs. traditional prescriptions of phosphodiesterase-5 inhibitors. [PDF]

Int J Impot Res, 2023
Schneider D, Loeb CA, Brevik A, El-Khatib F, Jenkins LC, Yafi FA.   +5 more
europepmc   +1 more source