Results 201 to 210 of about 79,270 (300)

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

open access: yesAdvanced Science, Volume 13, Issue 9, 13 February 2026.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng   +20 more
wiley   +1 more source

Sildenafil helps the beat go on

open access: yes
Experimental Physiology, EarlyView.
Jules C. Hancox
wiley   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton   +12 more
wiley   +1 more source

Outcomes of Aquablation in BPH with bladder stones: Analysis of the ICARUS database

open access: yesBJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objective The purpose of this study is investigate the clinical outcomes of men with benign prostatic hyperplasia (BPH) and bladder stones treated concomitantly with Aquablation and bladder stone removal in an international, multi‐institutional cohort.
Joshua D. Cabral   +25 more
wiley   +1 more source

Safety and efficacy of Rezūm water vapour energy therapy in BPH patients receiving antithrombotic therapy: A Japanese single‐centre experience

open access: yesBJUI Compass, Volume 7, Issue 2, February 2026.
Abstract Objectives The objective of this study is to evaluate the safety and efficacy of Rezūm water vapour energy therapy (WAVE) in Japanese patients with benign prostatic hyperplasia (BPH) continuing antithrombotic therapy and to validate the Okayama University Modified Clavien‐Dindo classification (OU‐mCD) for perioperative hematuria.
Takatoshi Moriwake   +13 more
wiley   +1 more source

The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension

open access: yesComprehensive Physiology, Volume 16, Issue 1, February 2026.
This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic ...
Lola Navarro‐Llinares   +3 more
wiley   +1 more source

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