Results 21 to 30 of about 112,243 (300)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia

Journal of the Endocrine Society, 2021
Abstract Background: Phosphoinositide 3-kinase inhibitors (PI3Ki) are a new class of medications used to treat HR positive, HER2 negative, PIK3CA mutated advanced or metastatic breast cancer. Inhibition of PI3K, a key enzyme in the insulin signaling pathway, leads to disruption of glucose metabolism and frequently hyperglycemia.
Shey, Susan, Kim, Sarah, Kim, Julie, Murphy, Elizabeth J   +3 more
openaire   +1 more source

Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors

Frontiers in Pharmacology, 2022
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3-kinase (PI3K) signaling pathway, mammalian target of rapamycin complex 2 ...
Hyunsoo Jang, Youngjun Park, Youngjun Park, Jaebong Jang   +3 more
doaj   +1 more source

Therapeutic Potential of Phosphoinositide 3-Kinase Inhibitors [PDF]

Chemistry & Biology, 2003
At least one Holy Grail for many academic researchers and pharmaceutical research divisions alike has been to identify therapeutically useful selective PI3K inhibitors. There are several different but closely related PI3Ks which are thought to have distinct biological roles.
Ward, Stephen, Sotsios, Yannis, Dowden, James, Bruce, Ian, Finan, Peter   +4 more
openaire   +2 more sources

Leveraging molecular structure and bioactivity with chemical language models for de novo drug design

Nature Communications, 2023
Generative Deep Learning holds promise for mining the unexplored “chemical universe” for new drugs. Here, the authors demonstrate the de novo design of phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors for the PI3K/Akt pathway in human tumor cells.
Michael Moret, Irene Pachon Angona, Leandro Cotos, Shen Yan, Kenneth Atz, Cyrill Brunner, Martin Baumgartner, Francesca Grisoni, Gisbert Schneider   +8 more
doaj   +1 more source

An updated review on activated PI3 kinase delta syndrome (APDS)

Genes and Diseases, 2020
Activated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary immunodeficiency disease. It has currently been a hot topic of clinical research and new data are emerging regarding its pathogenesis, clinical manifestations and ...
Ankita Singh, Vibhu Joshi, Ankur Kumar Jindal, Babu Mathew, Amit Rawat   +4 more
doaj   +1 more source

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor [PDF]

Biochemical Journal, 2007
Resveratrol, a polyphenol found in fruits, possesses chemopreventive and chemotherapeutic properties and has been shown to increase lifespan in yeast and metazoans, including mice. Genetic evidence and in vitro enzymatic measurements indicate that the deacetylase Sir2/SIRT1, an enzyme promoting stress resistance and aging, is the target of resveratrol.
Fröjdö, Sara, Cozzone, Delphine, Vidal, Hubert, Pirola, Luciano   +3 more
openaire   +4 more sources

Overview of Research into mTOR Inhibitors

Molecules, 2022
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that belongs to the phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family.
Beibei Mao, Qi Zhang, Li Ma, Dong-Sheng Zhao, Pan Zhao, Peizheng Yan   +5 more
doaj   +1 more source

Immunodeficiency due to a novel variant in PIK3CD: a case report

Pediatric Rheumatology Online Journal, 2023
Background Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide ...
Niloofar Shashaani, Zahra Chavoshzadeh, Leila Ghasemi, Shabnam Hajiani Ghotbabadi, Sara Shiari, Samin Sharafian, Reza Shiari   +6 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +2 more sources

Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer [PDF]

Current Oncology Reports, 2010
The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival. PI3K is activated in human cancers by elevated receptor tyrosine kinase activity, RAS mutation, as well as by mutation, amplification, and deletion of genes encoding components of the pathway.
James M, Cleary, Geoffrey I, Shapiro
openaire   +2 more sources