Results 31 to 40 of about 193,906 (268)
Immunotherapy in breast cancer: A clinician's perspective
Journal of the National Cancer Center, 2021 Globally over 2 million women are diagnosed with breast cancer each year despite major advances in detection and treatment of the disease. Breast cancer is comprised of several distinct subtypes and understanding the heterogeneity of the disease has ...
Sibapriya Chaudhuri +2 more
doaj +1 more source
Journal of Cell Biology, 1999 The architectural complexity of the hepatocyte canalicular surface has prevented examination of apical membrane dynamics with methods used for other epithelial cells.
P. Tuma +3 more
semanticscholar +1 more source
PLoS ONE, 2017 Activated B-cell-like diffuse large B-cell lymphoma relies on B-cell receptor signaling to drive proliferation and survival. Downstream of the B-cell receptor, the key signaling kinases Bruton's tyrosine kinase and phosphoinositide 3-kinase δ offer ...
Anella Yahiaoui +9 more
doaj +1 more source
Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia [PDF]
Expert Opinion on Investigational Drugs, 2017 Introduction: Frontline chemotherapy is successful against chronic lymphocytic leukemia (CLL), but results in untoward toxicity. Further, prognostic factors, cytogenetic anomalies, and compensatory cellular signaling lead to therapy resistance or disease relapse. Therefore, for the past few years, development of targeted therapies is on the rise.
Hima V, Vangapandu +2 more
openaire +2 more sources
Targeted treatment of vascular anomalies
International Journal of Women's Dermatology, 2021 Vascular anomalies comprise an array of congenital developmental disorders that can lead to significant disfigurement and physiologic disarray. The vast multitude of clinical phenotypes has inherently led to misdiagnosis and patients and families ...
Ashley T. Ng, BS +2 more
doaj +1 more source
Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis
Japanese Journal of Clinical Immunology, 2007 Activation of PI3K is a key step of intracellular signaling involved in many cellular functions. PI3K inhibitors have shown anti-rheumatic effects on arthritis model in mice. PI3K is a potential therapeutic target of rheumatoid arthritis.
Naoto, Tamura, Kazuhiko, Haruta
openaire +3 more sources
Biomolecules, 2019 The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3 ...
Christina M. Buchanan +2 more
doaj +1 more source
Targeting Phosphoinositide 3-Kinase – Five Decades of Chemical Space Exploration
CHIMIA, 2021 Phosphoinositide 3-kinase (PI3K) takes a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more.
Chiara Borsari, Matthias P. Wymann
doaj +1 more source
Frontiers in Cellular Neuroscience, 2013 In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase ...
Rabea eMüller +6 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Dysregulation of phosphoinositide 3-kinase (PI3K) signaling is highly implicated in tumorigenesis, disease progression, and the development of resistance to the current standard of care treatments in breast cancer patients. This review discusses the role
Zhizhu Zhang, Ann Richmond, Ann Richmond
doaj +1 more source