Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK) [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair.
Xueqin Huang +11 more
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Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies [PDF]
Haematologica, 2014 The phosphoinositide 3-kinase pathway represents an important anticancer target because it has been implicated in cancer cell growth, survival, and motility. Recent studies show that PI3K may also play a role in the development of resistance to currently
Elias Jabbour +3 more
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Activated phosphoinositide 3‐kinase delta syndrome: Pathogenesis, clinical manifestations, and treatment [PDF]
Pediatric DiscoveryActivated phosphoinositide 3‐kinase delta syndrome (APDS) is an autosomal dominant inborn errors of immunity resulting from gain of function mutations in the PIK3CD gene or loss of function mutations in the PIK3R1 gene.
Ke Zhu +3 more
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A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer [PDF]
Nature CommunicationsThe deregulated activation of the phosphoinositide 3-kinase (PI3K) pathway is a hallmark of aggressive tumors with metabolic plasticity, eliciting their adaptation to the microenvironment and resistance to chemotherapy. A significant gap lies between the
Guillaume P. Andrieu +14 more
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Deconvolution of bulk RNA sequencing in activated phosphoinositide 3‐kinase δ syndrome [PDF]
The Clinical Respiratory Journal, 2023 Background Many gaps remain in our understanding of the immune and molecular characteristics that underlie activated phosphoinositide 3‐kinase delta syndrome (APDS). Methods We performed RNA sequencing of peripheral blood leukocytes obtained from a child
Xia Huang, Haiyan Gu
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Leniolisib: a novel treatment for activated phosphoinositide-3 kinase delta syndrome [PDF]
Frontiers in PharmacologyGraphical AbstractIC50 = 11 nM (PI3Kδ); 244 nM (PI3Kα); 424 nM (PI3Kβ), 2,230 nM (PI3Kγ).
Surya K. De, Surya K. De
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Inhibiting phosphoinositide 3-kinases [PDF]
Cancer Biology & Therapy, 2005 Commentary to:PWT-458, A Novel Pegylated-17-Hydroxywortmannin, Inhibits Phosphatidylinositol 3-Kinase Signaling and Suppresses Growth of Solid TumorsK. Yu, J. Lucas, T. Zhu, A. Zask, C. Gaydos, L. Toral-Barza, J. Gu, F. Li, I. Chaudhary, P. Cai, J. Lotvin, R. Petersen, M. Ruppen, M. Fawzi, S. Ayral-Kaloustian, J. Skotnicki, T. Mansour, P.
Yardena, Samuels +2 more
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Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease
Cells, 2022 Alzheimer’s disease (AD) is a common age-related neurodegenerative disease that leads to memory loss and cognitive function damage due to intracerebral neurofibrillary tangles (NFTs) and amyloid-β (Aβ) protein deposition.
Shaobin Yang +4 more
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Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Glioma is one of the common intracranial malignant tumors, but the specific mechanism was unclear. The expression level of choline kinase A (CHKA) is positively correlated with the malignant grade of glioma.
HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
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Immunodeficiency due to a novel variant in PIK3CD: a case report
Pediatric Rheumatology Online Journal, 2023 Background Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide ...
Niloofar Shashaani +6 more
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