Results 241 to 250 of about 425,150 (316)

The therapeutic role of exercise training during menopause for reducing vascular disease

Experimental Physiology, EarlyView.
Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing, Bert Bond, Kerrie L. Moreau, Jeff S. Coombes, Jenna L. Taylor   +4 more
wiley   +1 more source

Phosphoinositide 3-kinase (PI3K; PIK3CG) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer.

The Journal of the National Comprehensive Cancer Network, 2013
J. Lauring, B. Park, A. Wolff
semanticscholar   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway. [PDF]

World J Diabetes
Xiong SX, Huang LJ, Liu HS, Zhang XX, Li M, Cui YB, Shao C, Hu XL.   +7 more
europepmc   +1 more source

Phosphoinositide 3-kinase-γ (PI3Kγ) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

A novel macrolide/fluoroketolide, solithromycin (CEM‐101), reverses corticosteroid insensitivity via phosphoinositide 3‐kinase pathway inhibition

British Journal of Pharmacology, 2013
Y. Kobayashi, H. Wada, C. Rossios, D. Takagi, C. Charron, P. J. Barnes, Kazuhiro Ito   +6 more
semanticscholar   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D. [PDF]

Adv Ther
Tutein Nolthenius JB, Griffiths A, Dodd O, Wyn R, Enstone A, Whalen J.   +5 more
europepmc   +1 more source

Exercise intensity‐dependent cardiac telocyte expansion is associated with physiological growth despite JAK/STAT pathway inactivity in male Wistar rats

Experimental Physiology, EarlyView.
Abstract While exercise induces physiological cardiac growth, the underlying cellular mechanisms remain incompletely understood. This study investigated the role of cardiac telocytes (TCs) and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in mediating exercise intensity‐dependent cardiac adaptation.
Mahboobeh Borjian Fard, Siroos Choobineh, Rahman Soori, Zohreh Mazaheri   +3 more
wiley   +1 more source