Results 251 to 260 of about 18,679,675 (294)
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Journal of Surgical Research, 2015
We previously demonstrated that inhibiting phosphoinositide 3-kinase (PI3K) or activating L-type calcium channels blocked the anti-inflammatory effects of magnesium sulfate (MgSO₄). However, the question as which class I PI3K isoform (PI3Kα, PI3Kβ, PI3Kδ, or PI3Kγ) is involved in this regard remains unstudied.
Ping-Ying, Lee +5 more
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We previously demonstrated that inhibiting phosphoinositide 3-kinase (PI3K) or activating L-type calcium channels blocked the anti-inflammatory effects of magnesium sulfate (MgSO₄). However, the question as which class I PI3K isoform (PI3Kα, PI3Kβ, PI3Kδ, or PI3Kγ) is involved in this regard remains unstudied.
Ping-Ying, Lee +5 more
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Structure and function of phosphoinositide 3-kinases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1998Phosphoinositide kinases (PI3Ks) play an important role in mitogenic signaling and cell survival, cytoskeletal remodeling, metabolic control and vesicular trafficking. Here we summarize the structure-function relationships delineating the activation process of class I PI3Ks involving various domains of adapter subunits, Ras, and interacting proteins ...
Wymann MP, Pirola L
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The Chemical Biology of Phosphoinositide 3‐Kinases
ChemBioChem, 2012AbstractSince its discovery in the late 1980s, phosphoinositide 3‐kinase (PI3K), and its isoforms have arguably reached the forefront of signal transduction research. Regulation of this lipid kinase, its functions, its effectors, in short its entire signaling network, has been extensively studied. PI3K inhibitors are frequently used in biochemistry and
Wymann, M. P., Schultz, C.
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Form and flexibility in phosphoinositide 3-kinases
Biochemical Society Transactions, 2009PI3Ks (phosphoinositide 3-kinases) have important roles in a variety of cellular activities, including survival, proliferation, growth, shape, migration and intracellular sorting. Consistent with their function in cell survival and growth, the gene for the class Iα PI3K catalytic subunit is a common site of gain-of-function mutations in cancers ...
Roger, Williams +4 more
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Phosphoinositide 3‐kinases in cell migration
Biology of the Cell, 2009Cell migration is essential for many biological processes in animals and is a complex highly co‐ordinated process that involves cell polarization, actin‐driven protrusion and formation and turnover of cell adhesions. The PI3K (phosphoinositide 3‐kinase) family of lipid kinases regulate cell migration in many different cell types, both through direct ...
Cain, Robert J., Ridley, Anne J.
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Phosphoinositide 3-Kinases in Health and Disease
2012In the last decade, the availability of genetically modified animals has revealed interesting roles for phosphoinositide 3-kinases (PI3Ks) as signaling platforms orchestrating multiple cellular responses, both in health and pathology. By acting downstream distinct receptor types, PI3Ks nucleate complex signaling assemblies controlling several ...
GHIGO, Alessandra +3 more
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Class I phosphoinositide 3-kinases
The International Journal of Biochemistry & Cell Biology, 2003Phosphoinositide 3-kinases (PI3-kinases) are a family of enzymes that 3'-phosphorylate the inositol head group of membrane phosphoinositides. They are subdivided into three major classes (I, II and III) based on their structural homology, regulation and substrate specificity. It is now becoming clear that PI3-kinase isoforms are subject to differential
Karen E, Anderson, Shaun P, Jackson
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Phosphoinositide 3-kinases and membrane traffic
Trends in Cell Biology, 1996Phosphoinositide 3-kinases (PI 3-kinases) and their 3-phosphoinositide products were identified initially as components of intracellular signalling pathways emanating from cell surface receptors. A new role for 3-phosphoinositides in the constitutive movement o f proteins from one intracellular compartment to another was proposed with the discovery of ...
P R, Shepherd +2 more
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Phosphoinositide 3-kinase in immunological systems
Seminars in Immunology, 2002Phosphoinositide 3-kinases (PI3Ks) are an evolutionarily conserved family of signal transducing enzymes. A great variety of stimuli activate PI3K, leading to the transient accumulation of its lipid products in cell membranes. These lipids serve as second messengers to regulate the location and activity of an array of downstream effector molecules.
David A, Fruman, Lewis C, Cantley
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The phosphoinositide 3-kinase pathway and cancer
Expert Reviews in Molecular Medicine, 2005Human tumours emerge as the result of multiple genetic and epigenetic aberrations that allow the proto-cancer cell to escape normal social control. Many signal transduction pathways become constitutively active during this process, and one whose importance is increasingly being appreciated involves phosphoinositide 3-kinase (PI3-kinase).
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