Results 241 to 250 of about 18,679,675 (294)

CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD. [PDF]

Respir Res
Govoni M, Bassi M, Girardello L, Lucci G, Rony F, Charretier R, Galkin D, Faietti ML, Pioselli B, Modafferi G, Benfeitas R, Bonatti M, Miglietta D, Clark J, Pedersen F, Kirsten AM, Beeh KM, Kornmann O, Korn S, Ludwig-Sengpiel A, Watz H.   +20 more
europepmc   +1 more source

Dapagliflozin exerts anti-apoptotic effects by mitigating macrophage polarization via modulation of the phosphoinositide 3-kinase/protein kinase B signaling pathway. [PDF]

World J Diabetes
Xiong SX, Huang LJ, Liu HS, Zhang XX, Li M, Cui YB, Shao C, Hu XL.   +7 more
europepmc   +1 more source

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. [PDF]

Nat Struct Mol Biol
Chen CL, Syahirah R, Ravala SK, Yen YC, Klose T, Deng Q, Tesmer JJG.   +6 more
europepmc   +1 more source

Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. [PDF]

Biochem J
europepmc   +1 more source

The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D. [PDF]

Adv Ther
Tutein Nolthenius JB, Griffiths A, Dodd O, Wyn R, Enstone A, Whalen J.   +5 more
europepmc   +1 more source

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Phosphoinositide 3-kinase

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1997
Abstract Plants, yeast and animal cells contain phosphoinositide 3-kinase activities (PI3K), each of which is capable of transferring the terminal phosphate of ATP to the D-3 position of the inositol head groups of one or more of the substrates Ptdins, PtdIns4P, and PtdIns(4,5)P2 (see Chapter 1 and references therein).
Sebastian Pons, Deborah J Burks, Morris F White   +2 more
openaire   +4 more sources

Phosphoinositide 3-kinase signalling in the nucleolus

Advances in Biological Regulation, 2022
The phosphoinositide 3-kinase (PI3K) signalling pathway plays key roles in many cellular processes and is altered in many diseases. The function and mode of action of the pathway have mostly been elucidated in the cytoplasm. However, many of the components of the PI3K pathway are also present in the nucleus at specific sub-nuclear sites including ...
Andrea Papdiné, Morovicz, Fatemeh, Mazloumi Gavgani, Rhîan G, Jacobsen, Malene, Skuseth Slinning, Diana C, Turcu, Aurélia E, Lewis   +5 more
openaire   +2 more sources

The Phosphoinositide 3-Kinase Pathway

Science, 2002
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell
openaire   +2 more sources

Phosphoinositide 3-kinases

1999
Abstract Phosphoinositide 3OH-kinases (PI3Ks) are enzymes which can phosphorylate one or more membrane inositol lipids in the 3-position of the inositol ring; in vitro they can make phosphoinositide(3)phosphate (PtdIns(3)P), phospho- inositide(3,4)bisphosphate (PtdIns(3,4)P2), and phosphoinositide(3,4,5)triphos- phate (PtdIns(3,4,5)P3)
K E Anderson, L R Stephens,, P T Hawkins
openaire   +1 more source