Results 41 to 50 of about 425,150 (316)

Phosphoinositide 3-kinase signalling pathways [PDF]

Journal of Cell Science, 2001
ABSTRACT Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3′-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3. These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a ...
openaire   +2 more sources

Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury

Cells, 2022
Inflammatory cells contribute to the pathogenesis of renal ischemia-reperfusion injury (IRI). However, the signaling mechanisms underlying the infiltration of inflammatory cells into the kidney are not well understood.
Xiaogao Jin, Qinjun Chu, Liwei Sun, Melanie Tran, Yanlin Wang   +4 more
doaj   +1 more source

Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]

, 2015
BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G, Norris, JW, Pombo, M, Shirley, E, Tablin, F   +4 more
core   +1 more source

The phosphoinositide (PI) 3-kinase family [PDF]

Journal of Cell Science, 2003
![Figure][1] Phosphoinositide (PI) 3-kinase was first observed in 1984 as a minor inositol lipid kinase activity associated with immunoprecipitated oncogene products (e.g. Src, Abl and polyoma mT antigen) and present in activated growth factor receptor complexes (e.g. PDGF receptor).
Fiona M, Foster, Colin J, Traer, Siemon M, Abraham, Michael J, Fry   +3 more
openaire   +2 more sources

A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?

Frontiers in Endocrinology, 2012
The phosphoinositide 3-kinase and AKT (Protein Kinase B, PKB) signalling pathway (PI3K/AKT) plays a central role in the control of cell survival, growth and proliferation throughout the body.
Imelda Mary McGonnell, Agamemnon Emil Grigoriadis, Eric W-F. Lam, Joanne S Price, Andrew eSunters   +4 more
doaj   +1 more source

Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]

, 2009
In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +2 more
core   +2 more sources

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

Nature Communications, 2015
Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires ...
Daniel Schlam, R. Bagshaw, S. Freeman, R. Collins, T. Pawson, G. Fairn, S. Grinstein   +6 more
semanticscholar   +1 more source

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.

PLoS Biology, 2013
The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in cancer.
Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge   +14 more
doaj   +1 more source

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. [PDF]

, 2013
The phosphoinositide 3-kinase (PI3K) signaling cascade is a key mediator of cellular growth, survival and metabolism and is frequently subverted in human cancer.
Bentires-Alj, M, Brinkhaus, H, Cardiff, Robert, Klebba, I, Koren, S, Leroy, C, Meyer, D, Müller, M, Müller, U   +8 more
core   +2 more sources

Phosphoinositide 3‐kinase‐dependent activation of Rac [PDF]

FEBS Letters, 2003
The monomeric GTPase Rac and the lipid kinase phosphoinositide 3‐kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger phosphatidylinositol (3,4,5)‐triphosphate (PtdIns(3,4,5 ...
Welch, Heidi C.E., Coadwell, W.John, Stephens, Len R., Hawkins, Phillip T.   +3 more
openaire   +2 more sources