Secretory Phospholipases A2 in Plants [PDF]
Frontiers in Plant Science, 2019 Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
María Elisa Mariani +4 more
doaj +7 more sources
Secreted Phospholipases A2 in Hereditary Angioedema With C1-Inhibitor Deficiency [PDF]
Frontiers in Immunology, 2018 BackgroundHereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that
Stefania Loffredo +16 more
doaj +7 more sources
Human phospholipases A2: a functional and evolutionary analysis [PDF]
Вавиловский журнал генетики и селекции, 2023 Phospholipases A2 (PLA2) are capable of hydrolyzing the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids. The PLA2 superfamily enzymes are widespread and present in most mammalian cells and tissues, regulating metabolism,
I. I. Turnaev +2 more
doaj +2 more sources
Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]
Toxins, 2021 Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
doaj +2 more sources
Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
doaj +9 more sources
Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket [PDF]
Scientific Reports, 2022 African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane is covered by
Andrea Martos-Esteban +6 more
doaj +2 more sources
Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2. [PDF]
PLoS ONE, 2014 Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius +9 more
doaj +2 more sources
Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia [PDF]
Toxins, 2017 Animal venoms comprise a complex mixture of components that affect several biological systems. Based on the high selectivity for their molecular targets, these components are also a rich source of potential therapeutic agents.
Vanessa O. Zambelli +4 more
doaj +2 more sources
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2017 Phospholipases A2 (PLA2s) are enzymes found throughout the animal kingdom. They hydrolyze phospholipids in the sn-2 position producing lysophospholipids and unsaturated fatty acids, agents that can damage membranes.
Catherine A Vulfius +10 more
doaj +2 more sources
Calcium-independent phospholipases A2 and their roles in biological processes and diseases [PDF]
Journal of Lipid Research, 2015 Among the family of phospholipases A2 (PLA2s) are the Ca2+-independent PLA2s (iPLA2s) and they are designated group VI iPLA2s. In relation to secretory and cytosolic PLA2s, the iPLA2s are more recently described and details of their expression and roles ...
Sasanka Ramanadham +5 more
doaj +2 more sources