Results 41 to 50 of about 9,843 (241)
Secreted phospholipase A2 revisited [PDF]
Journal of Biochemistry, 2011 Phospholipase A(2) (PLA(2)) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 enzymes that possess PLA(2) or related activity have been identified in mammals. About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular
Hiroyasu Sato +3 more
openaire +3 more sources
Mammalian Phospholipase A2: Phospholipase A2 Receptor
Biological and Pharmaceutical Bulletin, 2004 The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire +4 more sources
Proteome and Peptidome of Vipera berus berus Venom
Molecules, 2016 Snake venom is a rich source of peptides and proteins with a wide range of actions. Many of the venom components are currently being tested for their usefulness in the treatment of many diseases ranging from neurological and cardiovascular to cancer.
Aleksandra Bocian +7 more
doaj +1 more source
A2: Mathematical relativity and other progress in classical gravity theory - a session report [PDF]
Gen Relativ Gravit (2014) 46:1695, 2013 We report on selected oral contributions to the A2 session "Mathematical relativity and other progress in classical gravity theory" of "The 20th International Conference on General Relativity and Gravitation (GR20)" in Warsaw.
arxiv +1 more source
Separation of variables for A2 Ruijsenaars model and new integral representation for A2 Macdonald polynomials [PDF]
J.Phys.A29:2779-2804,1996, 1996 Using the Baker-Akhiezer function technique we construct a separation of variables for the classical trigonometric 3-particle Ruijsenaars model (relativistic generalization of Calogero-Moser-Sutherland model). In the quantum case, an integral operator M is constructed from the Askey-Wilson contour integral.
arxiv +1 more source
Systemic lupus erythematosus and cardiovascular disease
Journal of Internal Medicine, Volume 293, Issue 1, Page 48-62, January 2023., 2023 Abstract The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment and care, but cardiovascular disease (CVD) still remains an important clinical problem, since the risk of CVD in SLE is much higher than among controls.
Johan Frostegård
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia +9 more
wiley +1 more source
From sound to meaning in the auditory cortex: A neuronal representation and classification analysis [PDF]
arXiv, 2023 The neural mechanisms underlying the comprehension of meaningful sounds are yet to be fully understood. While previous research has shown that the auditory cortex can classify auditory stimuli into distinct semantic categories, the specific contributions of the primary (A1) and the secondary auditory cortex (A2) to this process are not well understood.
arxiv
Accelerated Bone Healing via Electrical Stimulation
Advanced Science, EarlyView.Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun +4 more
wiley +1 more source
Secretory Phospholipase A2s in Insulin Resistance and Metabolism
Frontiers in Endocrinology, 2021 The phospholipases A2 (PLA2) superfamily encompasses enzymes commonly found in mammalian tissues and snake venom. Many of these enzymes have unique tissue distribution, function, and substrate specificity suggesting distinct biological roles. In the past,
Michael S. Kuefner
doaj +1 more source