Results 81 to 90 of about 10,873 (239)

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia

Cellular & Molecular Biology Letters
Phospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human selenoproteins. It plays an essential role in eliminating toxic lipid hydroxy peroxides, thus inhibiting ferroptosis and favoring cell
Patrick Auberger, Cécile Favreau, Coline Savy, Arnaud Jacquel, Guillaume Robert   +4 more
doaj   +1 more source

Selective control of cytosolic glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase mRNA stability by selenium supply [PDF]

FEBS Letters, 1996
Selenium depletion of H4 hepatoma cells reduced cytosolic glutathione peroxidase (cGSH‐Px) mRNA abundance but had no effect on phospholipid hydroperoxide glutathione peroxidase (PHGSH‐Px) mRNA abundance. Actinomycin D chase experiments showed that selenium depletion had no effect on the stability of PHGSH‐Px mRNA but decreased the stability of cGSH‐Px ...
Bermano, Giovanna, Arthur, John R., Hesketh, John E.   +2 more
openaire   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases

Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar, Triveni Kodi, Adarsh Gopinathan, Bharath Harohalli Byregowda, Krishnadas Nandakumar, Anoop Kishore   +5 more
wiley   +1 more source

Maternal reproductive health: Expression patterns of antioxidant enzyme selenoproteins of post-implantation embryos conceived by ethanol-treated murine mothers supplemented with α-tocopherol

Asian Pacific Journal of Reproduction, 2017
Objective: To investigate if the protective effect of α-tocopherol against the impact of ethanol on brain morphogenesis involved the activity of the selenoproteins phospholipid hydroperoxide glutathione peroxidase (PHGPx; GPx4) and selenoprotein P (SelPP)
Gliceria B Ramos, Noel F Alfonso, Glenn G Oyong, Aleli Jillian L Sia   +3 more
doaj   +1 more source

Cloning and Expression Analysis of Chicken Phospholipid‐Hydroperoxide Glutathione Peroxidase

Animal Biotechnology, 2003
Phospholipid-hydroperoxide glutathione peroxidase (GPX4 or PHGPX) is a unique selenium dependent glutathione peroxidase that reduces phospholipid, cholesterol, and cholesteryl ester hydroperoxides. Phospholipid-hydroperoxide glutathione peroxidase has been shown to exist as both a 197 amino acid mitochondrial targeting protein and as a 170 amino acid ...
Byung-Whi, Kong, Hyunggee, Kim, Douglas N, Foster   +2 more
openaire   +2 more sources

Proteomic analysis of apricot fruit during ripening [PDF]

, 2012
Ripening of climacteric fruits involves a complex network of biochemical and metabolic changes that make them palatable and rich in nutritional and health-beneficial compounds.
Arena, S, D'Ambrosio, C, Marra, M, Novi, G, Rocco, M, Scaloni, A, Verrillo, F, Viscosi, V   +7 more
core   +1 more source

Potential Anti‐Aging Effects of a Dietary Supplement From the Algal‐Derived Omega‐3 DHA in Aged SAMP 8 Mice

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Algal‐derived Omega‐3 DHA supplementation exerts significant anti‐aging and neuroprotective effects in SAMP8 mice. Algal Omega‐3 DHA effectively mitigates age‐related cognitive decline, enhances antioxidant defenses, and extends lifespan. Algal‐derived Omega‐3 DHA supplementation enhances cognitive function, attenuates oxidative stress, and reduces ...
Ming‐Yu Chou, I‐Hung Lin, Chia‐Jung Chen, Ting‐Jian Guo, Che‐An Lin, Dao‐Na Yang, Po‐Hsien Li, Yu‐Chen Li, Mei‐Due Yang, Chieh‐Chang Tien, Ruei‐Ze Lin, Ching‐Hsin Chi, Shih‐Yi Wang, Ming‐Fu Wang   +13 more
wiley   +1 more source

The role of peroxiredoxins in cancer [PDF]

, 2017
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite.
CAPALBO, CARLO, COPPA, Anna, D'INZEO, SONIA, GIANNINI, Giuseppe, NICOLUSSI, Arianna   +4 more
core   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source