Results 111 to 120 of about 3,020 (150)

ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC. [PDF]

Cell Death Dis
Deng L, Yang X, Zhang J, Zhou X, Ma R, Wu Z, Chen H.   +6 more
europepmc   +1 more source

Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts. [PDF]

Metabolomics
Terra C, Terrier O, Le Gouellec A.
europepmc   +1 more source

Glutamine metabolism remodels tumor-associated macrophage: mechanistic explorations and new strategies in translational medicine. [PDF]

Front Immunol
Cui J, Yan X, Song J.
europepmc   +1 more source

<i>H-</i>phosphinic analogs of natural amino acids: a novel and efficient treatment for preventing biodeterioration of treasured painted artworks. [PDF]

Front Microbiol
Zhgun AA, Khomutov MA, Avdanina DA, Troyan E, Dumina MV, Ermolyuk AA, Simonenko N, Shumikhin K, Khurs EN, Zhuikova Y, Varlamov VP, Shitov MV, Khomutov AR.   +12 more
europepmc   +1 more source

Key biochemical pathways during pregnancy in livestock: mechanisms regulating uterine and placental development and function. [PDF]

Reprod Fertil
Halloran KM, Stenhouse C.
europepmc   +1 more source

4‑Acetylantrocamol LT3 suppresses colorectal cancer growth and metastasis via PI3K/AKT and MAPK pathway modulation. [PDF]

Int J Mol Med
Lin KT, Hsieh YC, Chang PK, Lai CW, Lee SY, Yen IC.   +5 more
europepmc   +1 more source

Bioinformatics analysis of PSAT1 loss identifies downstream pathways regulated in EGFR mutant NSCLC and a selective gene signature for predicting the risk of relapse. [PDF]

Oncol Lett
Biyik-Sit R, Waigel S, Andreeva K, Rouchka E, Clem BF.   +4 more
europepmc   +1 more source

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Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of Cancers

Current Cancer Drug Targets, 2023
Abstract: Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis, de novo serine synthesis, citric acid cycle and one-carbon metabolism.
Yuping Chen
exaly   +3 more sources

Structural investigation and inhibitory response of halide on phosphoserine aminotransferase from Trichomonas vaginalis

Biochimica Et Biophysica Acta - General Subjects, 2016
Phosphoserine aminotransferase (PSAT) catalyses the second reversible step of the phosphoserine biosynthetic pathway in Trichomonas vaginalis, which is crucial for the synthesis of serine and cysteine.PSAT from T. vaginalis (TvPSAT) was analysed using X-ray crystallography, enzyme kinetics, and molecular dynamics simulations.The crystal structure of ...
Rohit Kumar Singh, Mohit Mazumder, Bhumika Sharma   +2 more
exaly   +3 more sources

Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations

Protein and Peptide Letters, 2021
: Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway, consisting of three different enzymes, namely: 3-phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP).
Rohit Kumar Singh, Devbrat Kumar, Samudrala Gourinath   +2 more
exaly   +3 more sources