Results 121 to 130 of about 2,949 (161)

Targeting amino acid in tumor therapy. [PDF]

Front Oncol
Ge M, Xu Y, Cui L, Huang E, Liu Z, Yin K.   +5 more
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Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of Cancers

Current Cancer Drug Targets, 2023
Abstract: Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis, de novo serine synthesis, citric acid cycle and one-carbon metabolism.
Yuping Chen, Xue Yang, Chaojie Li
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Downregulation of Phosphoserine aminotransferase 1 promotes tumorigenesis in Glioblastoma

The FASEB Journal, 2020
Glioblastoma (GBM) is a typical brain tumor with survival below ten percent at 5 years after diagnosis. The genetic alternation and histological features are integrated into the classification of gliomas for better clinical management of GBM.
Yung-chieh Chan, Shang-Pen Huang, Yu-Chan Chang, Michael Hsiao   +3 more
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Structural basis ofL-phosphoserine binding toBacillus alcalophilusphosphoserine aminotransferase

Acta Crystallographica Section D Biological Crystallography, 2013
Phosphoserine aminotransferase is a vitamin B6-dependent enzyme that catalyzes the reversible conversion of 3-phosphohydroxypyruvate to L-phosphoserine using glutamate as an amine donor. In an effort to gain insight into the substrate-recognition mechanism of the enzyme, crystal structures of Bacillus alcalophilus phosphoserine aminotransferase in the ...
Battula, Pradeep, Dubnovitsky, Anatoly P., PAPAGEORGIOU, ANASTASSIOS   +2 more
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Structure of phosphoserine aminotransferase fromMycobacterium tuberculosis

Acta Crystallographica Section D Biological Crystallography, 2012
Mycobacterium tuberculosis (Mtb), the causative agent of TB, remains a serious world health problem owing to limitations of the available drugs and the emergence of resistant strains. In this context, key biosynthetic enzymes from Mtb are attractive targets for the development of new therapeutic drugs.
Fasseli, Coulibaly, Edouard, Lassalle, Heather M, Baker, Edward N, Baker   +3 more
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Phosphoserine aminotransferase deficiency: imaging findings in a child with congenital microcephaly

The Journal of Maternal-Fetal & Neonatal Medicine, 2018
Serine deficiency disorders can result from deficiency in one of three enzymes. Deficiency of the second enzyme, 3-phosphoserine aminotransferase (PSAT), has been reported in two siblings; the eldest investigated for acquired microcephaly, spasticity and epilepsy. Our patient had neurological symptoms at birth. Fetal magnetic resonance imaging (MRI) at
Gali Shapira Zaltsberg, Hugh J. McMillan, Elka Miller   +2 more
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Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations

Protein & Peptide Letters, 2021
: Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway, consisting of three different enzymes, namely: 3-phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP).
Rohit Kumar Singh, Devbrat Kumar, Samudrala Gourinath   +2 more
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Phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus: purification, gene cloning and sequencing

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1996
Two peaks of aspartate aminotransferase (AspAT) catalytic activity were observed during DEAE chromatography of a protein extract from alkalophilic B. circulans. The enzyme purified from the major peak appeared to be not aspartate but phosphoserine aminotransferase (PSAT) with a considerably high AspAT side activity.
N, Battchikova, J P, Himanen, M, Ahjolahti, T, Korpela   +3 more
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Novel protein–protein interactions between Entamoeba histolytica d-phosphoglycerate dehydrogenase and phosphoserine aminotransferase

Biochimie, 2012
Physical interactions between d-phosphoglycerate dehydrogenase (EhPGDH) and phosphoserine aminotransferase (EhPSAT) from an enteric human parasite Entamoeba histolytica was observed by pull-down assay, gel filtration chromatography, chemical cross-linking, emission anisotropy, molecular docking and molecular dynamic simulations.
Vibhor, Mishra, Ashutosh, Kumar, Vahab, Ali, Tomoyoshi, Nozaki, Kam Y J, Zhang, Vinod, Bhakuni   +5 more
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Serine metabolism in legume nodules: Purification and properties of phosphoserine aminotransferase

Physiologia Plantarum, 1988
Enzymes involved in serine metabolism were compared in the plant cytosol fraction of root nodules from soybean [Glycine max (L.) Merr., cv. Amsoy] and lupin [Lupinus angustifolius L., cv. Uniharvest]. Soybean nodules are ureide exporters and have a serine requirement in the synthesis of these compounds, whereas lupin nodules are amide transporters and ...
Paul H. S. Reynolds, Anna Hine, Karen Rodber   +2 more
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