Results 141 to 150 of about 163,724 (193)
Biotechnology Journal, 2019 Phosphoserine aminotransferase (SerC) from Escherichia coli (E. coli) MG1655 is engineered to catalyze the deamination of homoserine to 4-hydroxy-2-ketobutyrate, a key reaction in producing 1,3-propanediol (1,3-PDO) from glucose in a novel glycerol ...
An-Ping Zeng +2 more
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Protein and Peptide Letters, 2021
Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway, consisting of three different enzymes, namely: 3-phosphoglycerate dehydrogenase (PGDH ...
Samudrala Gourinath +2 more
exaly +4 more sources
Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway, consisting of three different enzymes, namely: 3-phosphoglycerate dehydrogenase (PGDH ...
Samudrala Gourinath +2 more
exaly +4 more sources
Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of Cancers.
Current Cancer Drug Targets, 2022Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis,
Yuping Chen, Xue Yang, Chaojie Li
semanticscholar +3 more sources
Phosphoserine aminotransferase deficiency: imaging findings in a child with congenital microcephaly
The Journal of Maternal-Fetal & Neonatal Medicine, 2018Serine deficiency disorders can result from deficiency in one of three enzymes. Deficiency of the second enzyme, 3-phosphoserine aminotransferase (PSAT), has been reported in two siblings; the eldest investigated for acquired microcephaly, spasticity and
Gali Shapira-Zaltsberg +2 more
semanticscholar +3 more sources
Archives of Biochemistry and Biophysics
BACKGROUND Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to
O. Minchenko +6 more
semanticscholar +3 more sources
BACKGROUND Endoplasmic reticulum stress and synthesis of serine are essential for tumor growth, but the mechanism of their interaction is not clarified yet. The overarching goal of this work was to investigate the impact of ERN1 (endoplasmic reticulum to
O. Minchenko +6 more
semanticscholar +3 more sources
Phosphoserine Aminotransferase, the Second Step-Catalyzing Enzyme for Serine Biosynthesis [PDF]
IUBMB Life, 1999 AbstractAs a step toward analyzing the serine biosynthetic pathway in mammals, we have studied the properties of phosphoserine aminotransferase, the second step‐catalyzing enzyme. The Km values for 3‐phosphohydroxypyruvate and L‐phosphoserine are 5 and 35 mu M, respectively, and those for glutamate and alpha‐ketoglutarate are 1.2 and 0.8 mM ...
M J, Basurko +3 more
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Molecular and Cellular Biology/Genetics, 2021
Phosphoserine aminotransferase 1 (PSAT1) catalyzes the second enzymatic step within the serine synthetic pathway and its expression is elevated in numerous human cancers, such as NSCLC.
Rumeysa Biyik‐Sit, B. Clem
semanticscholar +1 more source
Phosphoserine aminotransferase 1 (PSAT1) catalyzes the second enzymatic step within the serine synthetic pathway and its expression is elevated in numerous human cancers, such as NSCLC.
Rumeysa Biyik‐Sit, B. Clem
semanticscholar +1 more source
Investigation Of Phosphoserine Aminotransferase 1 And Its Role In Breast Cancer Progression
The FASEB Journal, 2018 Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
B. Clem +3 more
semanticscholar +2 more sources
Structure of phosphoserine aminotransferase fromMycobacterium tuberculosis
Acta Crystallographica Section D Biological Crystallography, 2012Mycobacterium tuberculosis (Mtb), the causative agent of TB, remains a serious world health problem owing to limitations of the available drugs and the emergence of resistant strains. In this context, key biosynthetic enzymes from Mtb are attractive targets for the development of new therapeutic drugs.
Fasseli, Coulibaly +3 more
openaire +2 more sources