Results 141 to 150 of about 46,144 (173)

Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations

Protein and Peptide Letters, 2021
: Serine is ubiquitously synthesized in all living organisms from the glycolysis intermediate 3-phosphoglycerate (PGA) by phosphoserine biosynthetic pathway, consisting of three different enzymes, namely: 3-phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP).
Samudrala Gourinath, Devbrat Kumar, Rohit Kumar Singh   +2 more
exaly   +3 more sources

Structural investigation and inhibitory response of halide on phosphoserine aminotransferase from Trichomonas vaginalis

Biochimica Et Biophysica Acta - General Subjects, 2016
Phosphoserine aminotransferase (PSAT) catalyses the second reversible step of the phosphoserine biosynthetic pathway in Trichomonas vaginalis, which is crucial for the synthesis of serine and cysteine.PSAT from T. vaginalis (TvPSAT) was analysed using X-ray crystallography, enzyme kinetics, and molecular dynamics simulations.The crystal structure of ...
Bhumika Sharma, Mohit Mazumder, Samudrala Gourinath   +2 more
exaly   +3 more sources

Novel protein–protein interactions between Entamoeba histolytica d-phosphoglycerate dehydrogenase and phosphoserine aminotransferase

Biochimie, 2012
Physical interactions between d-phosphoglycerate dehydrogenase (EhPGDH) and phosphoserine aminotransferase (EhPSAT) from an enteric human parasite Entamoeba histolytica was observed by pull-down assay, gel filtration chromatography, chemical cross-linking, emission anisotropy, molecular docking and molecular dynamic simulations.
Vibhor Mishra, Vahab Ali, Kam Zhang
exaly   +3 more sources

Phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus: purification, gene cloning and sequencing

BBA - Proteins and Proteomics, 1996
Two peaks of aspartate aminotransferase (AspAT) catalytic activity were observed during DEAE chromatography of a protein extract from alkalophilic B. circulans. The enzyme purified from the major peak appeared to be not aspartate but phosphoserine aminotransferase (PSAT) with a considerably high AspAT side activity.
Natalia Battchikova, Timo Korpela, T Korpela   +2 more
exaly   +3 more sources

Association of DNA Methylation of Phosphoserine Aminotransferase with Response to Endocrine Therapy in Patients with Recurrent Breast Cancer

Cancer Research, 2005
Abstract To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor–positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy.
Martens, John, Nimmrich, I, Koenig, T, Look, Maxime, Harbeck, N, Model, F, Kluth, A, de Vries, J, Sieuwerts, Anieta, Portengen, H (Henk), Gelder, MEM, Piepenbrock, C, Olek, A, Hofler, H, Kiechle, M, Klijn, Jan, Schmitt, M, Maier, S, Foekens, John   +18 more
openaire   +4 more sources

Downregulation of Phosphoserine aminotransferase 1 promotes tumorigenesis in Glioblastoma

The FASEB Journal, 2020
Glioblastoma (GBM) is a typical brain tumor with survival below ten percent at 5 years after diagnosis. The genetic alternation and histological features are integrated into the classification of gliomas for better clinical management of GBM.
Yung-chieh Chan, Shang-Pen Huang, Yu-Chan Chang, Michael Hsiao   +3 more
openaire   +1 more source

Engineering of Phosphoserine Aminotransferase Increases the Conversion of l‐Homoserine to 4‐Hydroxy‐2‐ketobutyrate in a Glycerol‐Independent Pathway of 1,3‐Propanediol Production from Glucose

Biotechnology Journal, 2019
Phosphoserine aminotransferase (SerC) from Escherichia coli (E. coli) MG1655 is engineered to catalyze the deamination of homoserine to 4-hydroxy-2-ketobutyrate, a key reaction in producing 1,3-propanediol (1,3-PDO) from glucose in a novel glycerol ...
An-Ping Zeng
exaly   +3 more sources

Structure of phosphoserine aminotransferase fromMycobacterium tuberculosis

Acta Crystallographica Section D Biological Crystallography, 2012
Mycobacterium tuberculosis (Mtb), the causative agent of TB, remains a serious world health problem owing to limitations of the available drugs and the emergence of resistant strains. In this context, key biosynthetic enzymes from Mtb are attractive targets for the development of new therapeutic drugs.
Fasseli, Coulibaly, Edouard, Lassalle, Heather M, Baker, Edward N, Baker   +3 more
openaire   +2 more sources

Phosphoserine aminotransferase deficiency: imaging findings in a child with congenital microcephaly

The Journal of Maternal-Fetal & Neonatal Medicine, 2018
Serine deficiency disorders can result from deficiency in one of three enzymes. Deficiency of the second enzyme, 3-phosphoserine aminotransferase (PSAT), has been reported in two siblings; the eldest investigated for acquired microcephaly, spasticity and epilepsy. Our patient had neurological symptoms at birth. Fetal magnetic resonance imaging (MRI) at
Gali Shapira Zaltsberg, Hugh J. McMillan, Elka Miller   +2 more
openaire   +2 more sources

Serine metabolism in legume nodules: Purification and properties of phosphoserine aminotransferase

Physiologia Plantarum, 1988
Enzymes involved in serine metabolism were compared in the plant cytosol fraction of root nodules from soybean [Glycine max (L.) Merr., cv. Amsoy] and lupin [Lupinus angustifolius L., cv. Uniharvest]. Soybean nodules are ureide exporters and have a serine requirement in the synthesis of these compounds, whereas lupin nodules are amide transporters and ...
Paul H. S. Reynolds, Anna Hine, Karen Rodber   +2 more
openaire   +1 more source