Results 71 to 80 of about 2,949 (161)

Colorectal Cancer Cells Promote de novo Glycine Synthesis for Collagen Production in Cancer‐Associated Fibroblasts by Secreting TGF‐β1

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Cancer‐associated fibroblasts (CAFs) exhibit profound amino acid reprogramming, especially the production of glycine in colorectal cancer (CRC). CRC cell‐derived TGF‐β1 activates de novo glycine synthesis in CAFs, promoting collagen production. The pharmacological inhibition of PHGDH, the rate‐limiting enzyme of de novo glycine synthesis pathway ...
Chunqi Liu, Huaqin Zhang, Jin Gong, Yuzhou Xiao, Yiyun Lin, Wen Peng, Xiaodan Pan, Yan Li, Hui Jie, Xinying Qian, Na Sang, Lei Tao, Na Su, Jing Wei, Xiaobo Cen, Xiao Du, Yinglan Zhao   +16 more
wiley   +1 more source

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

Frontiers in Cellular Neuroscience
IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH)
Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti   +9 more
doaj   +1 more source

Mitochondria ATP Pro‐Ferroptosis by Adjusting the Conversion of PUFA to PUFA‐PLs

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Glutamine deprivation can promote PUFA oxidation and PTGS2 expression through the upregulation of intracellular ROS, but not ferroptosis. Because glutamine deficiency exhausts mitochondrial ATP, thereby hinders the conversion of PUFA into their active form of PUFA‐CoA needed for lipid synthesis.
Chaoyi Xia, Lianchao Gao, Jingshu Min, Caiyun Fu   +3 more
wiley   +1 more source

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +1 more source

Natural Variation in SER1 and ENA6 Underlie Condition-Specific Growth Defects in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2018
Despite their ubiquitous use in laboratory strains, naturally occurring loss-of-function mutations in genes encoding core metabolic enzymes are relatively rare in wild isolates of Saccharomyces cerevisiae.
Amy Sirr, Adrian C. Scott, Gareth A. Cromie, Catherine L. Ludlow, Vida Ahyong, Trey S. Morgan, Teresa Gilbert, Aimée M. Dudley   +7 more
doaj   +1 more source

P.067 Phosphoserine aminotransferase (PSAT) deficiency: Imaging findings in a child with congenital microcephaly [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2018
Background: Serine deficiency disorders can result from deficiency in one of three enzymes. Deficiency of the second enzyme in the serine biosynthesis pathway, 3-phosphoserine aminotransferase (PSAT), has been reported in two siblings when the eldest was investigated for acquired microcephaly, progressive spasticity and intractable epilepsy.
G Shapira Zaltsberg, H McMillan, E Miller   +2 more
openaire   +1 more source

PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress

Diagnostic Pathology
Background Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which
Xiaofeng Du, Yanting Wang, Fan Gao
doaj   +1 more source

Abundance and functional diversity of riboswitches in microbial communities

BMC Genomics, 2007
Background Several recently completed large-scale enviromental sequencing projects produced a large amount of genetic information about microbial communities ('metagenomes') which is not biased towards cultured organisms.
Gelfand Mikhail S, Vitreschak Alexey G, Kazanov Marat D   +2 more
doaj   +1 more source

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Journal of Translational Medicine, 2019
Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC.
Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong   +3 more
doaj   +1 more source

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii

Parasites & Vectors, 2018
Background Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis.
Duo Wu, Meng Feng, Zhi-xin Wang, Ke Qiao, Hiroshi Tachibana, Xun-jia Cheng   +5 more
doaj   +1 more source