Results 41 to 50 of about 12,613 (178)

Protein Glutamylation: From Cytoskeleton to Signaling

Med Research, EarlyView.
Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen, Yi Yuan, Qingquan Yu, Xinyue Wang, Hui Wang   +4 more
wiley   +1 more source

Fatty acid composition of Drosophila photoreceptor light-sensitive microvilli

Biological Research, 2013
Phototransduction, the mechanism underlying the electrical response to light in photoreceptor cells, has been thoroughly investigated in Drosophila melanogaster, an essential model in signal transduction research. These cells present a highly specialized
Yorka Muñoz, Karen Fuenzalida, Miguel Bronfman, Arnaldo Gatica, Marcelo Sepúlveda, Juan Bacigalupo, Alejandro D Roth, Ricardo Delgado   +7 more
doaj   +1 more source

Adaptation memory in photoreceptors: different mechanisms in rods and cones

Frontiers in Molecular Neuroscience, 2023
Vertebrate rods and cones operate over a wide range of ambient illumination, which is provided by light adaptation mechanisms regulating the sensitivity and speed of the phototransduction cascade.
Darya A. Nikolaeva, Maria A. Nekrasova, Alexander Yu. Rotov, Alexander Yu. Rotov, Luba A. Astakhova   +4 more
doaj   +1 more source

Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris

Integrative Zoology, EarlyView.
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli, Al‐Sayed Al‐Soudy, Mariangela Norcia, Stefania Galdiero, Sara Palladino, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +7 more
wiley   +1 more source

Calcium-sensor proteins but not bicarbonate ion activate retinal photoreceptor membrane guanylyl cyclase in photoreceptors

Frontiers in Molecular Neuroscience
Retinal membrane guanylyl cyclase (RetGC), regulated by guanylyl cyclase activating proteins (GCAPs) via negative calcium-feedback, is one of the most critically important enzymes in vertebrate rod and cone physiology, enabling their sensitivity to light.
Igor V. Peshenko, Elena V. Olshevskaya, Alexander M. Dizhoor, Alexander M. Dizhoor   +3 more
doaj   +1 more source

One Actor, Multiple Roles: The Performances of Cryptochrome in Drosophila

Frontiers in Physiology, 2020
Cryptochromes (CRYs) are flavoproteins that are sensitive to blue light, first identified in Arabidopsis and then in Drosophila and mice. They are evolutionarily conserved and play fundamental roles in the circadian clock of living organisms, enabling ...
Milena Damulewicz, Gabriella M. Mazzotta
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

cGMP-dependent pathway and a GPCR kinase are required for photoresponse in the nematode Pristionchus pacificus.

PLoS Genetics
Light sensing is a critical function in most organisms and is mediated by photoreceptor proteins and phototransduction. Although most nematodes lack eyes, some species exhibit phototaxis.
Kenichi Nakayama, Hirokuni Hiraga, Aya Manabe, Takahiro Chihara, Misako Okumura   +4 more
doaj   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Model of Phototransduction in Retinal Rods

Cold Spring Harbor Symposia on Quantitative Biology, 1990
Phototransduction is the process by which the absorption of a photon by a molecule of rhodopsin in a photoreceptor is transformed into an electrical signal. This electrical signal is caused by the modulation of a current, usually called photocurrent, flowing across the light-sensitive channels in the plasma membrane of outer segments.
Torre V., Forti S., Menini, Anna, Campani M.   +3 more
openaire   +4 more sources