Results 61 to 70 of about 14,467 (226)

Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics

Frontiers in Cellular Neuroscience, 2021
The past decades have seen tremendous progress in our understanding of the function of photoreceptors and olfactory sensory neurons, uncovering the mechanisms that determine their properties and, ultimately, our ability to see and smell.
Federica Genovese, Johannes Reisert, Vladimir J. Kefalov, Vladimir J. Kefalov   +3 more
doaj   +1 more source

Model of Phototransduction in Retinal Rods

Cold Spring Harbor Symposia on Quantitative Biology, 1990
Phototransduction is the process by which the absorption of a photon by a molecule of rhodopsin in a photoreceptor is transformed into an electrical signal. This electrical signal is caused by the modulation of a current, usually called photocurrent, flowing across the light-sensitive channels in the plasma membrane of outer segments.
Torre V., Forti S., Menini, Anna, Campani M.   +3 more
openaire   +4 more sources

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Evolution of vertebrate phototransduction : cascade activation [PDF]

, 2016
We applied high-throughput sequencing to eye tissue from several species of basal vertebrates (a hagfish, two species of lamprey, and five species of gnathostome fish), and we analyzed the mRNA sequences for the proteins underlying activation of the ...
Aaron Chuah, Lamb, Trevor D, Riccardo C. Natoli, Hunt, David M, Chuah, Aaron, David M. Hunt, Davies, Wayne I. L, Patel, Hardip, Collin, Shaun P, Hardip Patel, Shaun P. Collin, Lamb, Trevor, Trevor D. Lamb, Hart, Nathan S, Wayne I. L. Davies, Natoli, Riccardo C, Davies, Wayne I L, Nathan S. Hart   +17 more
core   +1 more source

Multiple Roles of cAMP in Vertebrate Retina

Cells, 2023
cAMP is a key regulatory molecule that controls many important processes in the retina, including phototransduction, cell development and death, growth of neural processes, intercellular contacts, retinomotor effects, and so forth.
Natalia Erofeeva, Darya Meshalkina, Michael Firsov   +2 more
doaj   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

Neural Regeneration Research
Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell death. However, there is no effective treatment for retinitis pigmentosa caused by PDE6B mutation.
Ruiqi Qiu, Mingzhu Yang, Xiuxiu Jin, Jingyang Liu, Weiping Wang, Xiaoli Zhang, Jinfeng Han, Bo Lei   +7 more
doaj   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Distinctive gene expression in the reduced first thoracic legs of a nymphalid butterfly

Insect Molecular Biology, EarlyView.
Transcriptome analysis reveals that the small non‐walking front legs of a butterfly have distinct gene expression to the four walking legs. Reduced front legs express a gene with putative mechanosensory roles, a blue‐sensitive opsin and two homeobox genes.
Asia E. Hoile, Peter O. Mulhair, Peter W. H. Holland   +2 more
wiley   +1 more source

Cnidocyte discharge is regulated by light and opsin-mediated phototransduction

BMC Biology, 2012
Background Cnidocytes, the eponymous cell type of the Cnidaria, facilitate both sensory and secretory functions and are among the most complex animal cell types known.
Plachetzki David C, Fong Caitlin R, Oakley Todd H   +2 more
doaj   +1 more source