Results 51 to 60 of about 12,613 (178)

Ultrafast Transient Absorption Spectra and Kinetics of Rod and Cone Visual Pigments

Molecules, 2023
Rods and cones are the photoreceptor cells containing the visual pigment proteins that initiate visual phototransduction following the absorption of a photon.
Arjun Krishnamoorthi, Keyvan Khosh Abady, Dinesh Dhankhar, Peter M. Rentzepis   +3 more
doaj   +1 more source

Kcnv2 E151X Mouse Captures Hallmarks of KCNV2‐Associated Retinal Dystrophy

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Nermina Xhaferri, Sumit Biswas, Benjamin Davies, Moritz Lindner   +3 more
wiley   +1 more source

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

Neural Regeneration Research
Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell death. However, there is no effective treatment for retinitis pigmentosa caused by PDE6B mutation.
Ruiqi Qiu, Mingzhu Yang, Xiuxiu Jin, Jingyang Liu, Weiping Wang, Xiaoli Zhang, Jinfeng Han, Bo Lei   +7 more
doaj   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

The Insect Eye: From Foundational Biology to Modern Applications in Pest Management

Insects
The ability of an animal to perceive its visual environment underpins many behaviors essential to survival, including navigation, foraging, predator avoidance, and recognition of conspecific individuals, making vision a critical element of both ...
Marianna Varone, Paola Di Lillo, Francesca Lucibelli, Gennaro Volpe, Angela Carfora, Sarah Maria Mazzucchiello, Serena Aceto, Giuseppe Saccone, Marco Salvemini   +8 more
doaj   +1 more source

Prolonged rod photoresponse and enhanced cone sensitivity in the transgenic mouse retina lacking arrestin and guanylate cyclase activating proteins

The Journal of Physiology, EarlyView.
Abstract figure legend Analyses from mutant mouse retinal explants gives invaluable insights of the photosignaling process in rod and cone photoreceptor cells. A, Illustration of retinal photovoltage recordings. A retinal explant (pink) is placed in a transparent device which has electrodes to monitor transretinal voltage (red and blue circles).
Shinya Sato, Rikard Frederiksen, Alapakkam P. Sampath, Vladimir J. Kefalov   +3 more
wiley   +1 more source

Lycium barbarum glycopeptide protects against inherited retinal degeneration in rd10 mice by regulating phototransduction and neuroinflammatory pathways

Neural Regeneration Research
Inherited retinal degenerative diseases, such as retinitis pigmentosa, cause progressive photoreceptor loss and irreversible vision decline, yet effective treatments remain unavailable.
Taimin Guo, Zhicheng Zhou, Jiannan Tang, Kwok-Fai So, Xuesong Mi, Ying Xu   +5 more
doaj   +1 more source

A Multi‐Tissue Transcriptomic Resource for the Brahminy Blindsnake Indotyphlops braminus (Squamata: Typhlopidae)

Ecology and Evolution, Volume 16, Issue 11, November 2026.
We analyzed multi‐tissue expression patterns in the all‐female, parthenogenetic, and triploid Brahminy blindsnake (Indotyphlops braminus) using PacBio and Illumina RNA‐seq to better understand polyploidy and asexual reproduction in vertebrates. By characterizing differential expression and co‐expression networks across the ovary, heart, liver, skin ...
Kexin Sun, Xiang Ji, Jing Lu, Anqiong Lu, Yuqian Wang, Fei Zhu   +5 more
wiley   +1 more source

Ten‐Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova, Michelle Fleishaker, Byron L. Lam, Dmitry Ivanov   +3 more
wiley   +1 more source

RGS9, a GTPase Accelerator for Phototransduction [PDF]

Neuron, 1998
The rod outer segment phototransduction GAP (GTPase-accelerating protein) has been identified as RGS9, a member of the RGS family of G alpha GAPs. RGS9 mRNA expression is specific for photoreceptor cells, and RGS9 protein colocalizes with other phototransduction components to photoreceptor outer segment membranes. The RGS domain of RGS9 accelerates GTP
He, Wei, Cowan, Christopher W, Wensel, Theodore G   +2 more
openaire   +2 more sources