Results 1 to 10 of about 626,720 (343)

Targeting PI3K/Akt signal transduction for cancer therapy

Signal Transduction and Targeted Therapy, 2021
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors.
Bin Li
exaly   +2 more sources

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne, Falkenburg, J. H. Frederik, Liebermann, Marcus, Nijmeijer, Bart A., Ottmann, Oliver Gerhard, Pfeifer, Heike, Ruthardt, Martin, Tesanovic, Tamara, Wystub, Sylvia   +8 more
core   +25 more sources

PI3K inhibitors are finally coming of age

Nature Reviews Drug Discovery, 2021
, Matthew W D Perry, Jennifer R Brown
exaly   +2 more sources

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Nature, 2018
Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among
Benjamin D Hopkins, Chantal Pauli, David Wu   +2 more
exaly   +2 more sources

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Nature Reviews Cancer, 2019
Gerta Hoxhaj, Brendan D Manning
exaly   +2 more sources

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature Reviews Clinical Oncology, 2022
Neil Vasan, Lewis C Cantley
exaly   +2 more sources

PI3K and cancer: lessons, challenges and opportunities

Nature Reviews Drug Discovery, 2014
David A Fruman
exaly   +2 more sources

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Molecular Cancer, 2023
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression.
Antonino Glaviano, A. S. Foo, H. Y. Lam, K. C. Yap, W. Jacot, Robert H. Jones, Huiyan Eng, M. Nair, Pooyan Makvandi, B. Geoerger, M. Kulke, R. Baird, J. Prabhu, D. Carbone, Camilla Pecoraro, D. B. Teh, G. Sethi, V. Cavalieri, Kevin H. Lin, Nathalie Javidi-Sharifi, Eneda Toska, M. Davids, Jennifer R. Brown, P. Diana, J. Stebbing, D. Fruman, A. Kumar   +26 more
semanticscholar   +1 more source

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU, Shanshan YANG, Chunchan ZHENG, Sujun LUO, Na WEI, Sirui LI, Jianqiang SHI, Rongyi CHEN   +7 more
doaj   +1 more source

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

eLife, 2022
Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia, Mohammad Ekhlak, Geeta Kushwaha, Vipin Singh, Ram L Mallick, Debabrata Dash   +5 more
doaj   +1 more source