Results 11 to 20 of about 626,720 (343)

Characterization of Cutaneous Adverse Events Associated With PI3K Inhibitors in 11 Patients [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
Introduction: Phosphoinositide 3-kinase (PI3K) inhibitors are a new class of cancer therapeutics that inhibits one or more enzymes in the PI3K/AKT/mTOR tumor growth pathway.
Padmavathi V. Karri, Benjamin D. Freemyer, Omar Pacha, Anisha B. Patel   +3 more
doaj   +1 more source

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

International Journal of Molecular Sciences, 2023
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. Metabolic reprogramming is considered a new hallmark of cancer, but it remains unclearly described in HCC. The dysregulation of the PI3K/AKT/mTOR signaling
Ling-Yu Tian, Daniel J. Smit, M. Jücker
semanticscholar   +1 more source

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

Frontiers in Oncology, 2022
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also an impediment to improving life expectancy worldwide. Furthermore, the global burden of cancer incidence and death is continuously growing.
Yan Peng, Yuanyuan Wang, Cheng Zhou, W. Mei, Changchun Zeng   +4 more
semanticscholar   +1 more source

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Frontiers in Pharmacology, 2021
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase ...
Hui-Zhi Long, Yan Cheng, Zi-Wei Zhou, Hong-Yu Luo, Dan-Dan Wen, Lichen Gao   +5 more
semanticscholar   +1 more source

Berberine Supplement and Resistance Training May Ameliorate Diazinon Induced Neural Toxicity in Rat Hippocampus Via the Activation of the TrkB and ERK Signaling Pathway

International Clinical Neuroscience Journal, 2020
Background: Diazinon is an organophosphate pesticide that is broadly applied to control insects which causes oxidative damages in hippocampus tissue.
Elham Shakouri, Mohammad Ali Azarbayjani, Seyed Behnamedin Jameie, Maghsoud Peeri, Mona Farhadi   +4 more
doaj   +1 more source

PI3K Pathway in NSCLC [PDF]

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3'-hydroxyl group of phosphatidylinositol and phosphoinositides. PI3K regulate signaling pathways for neoplasia, including cell proliferation, adhesion, survival, and motility.
Martinez-Martí, Alex, Felip, Enriqueta
openaire   +3 more sources

Cortactin Could Regulate Proliferation and Apoptosis of Esophageal Squamous Carcinoma Cells Through PI3K-AKT Pathway

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the effects and potential regulatory mechanisms of Cortactin (CTTN) on the proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC).
ZHANG Jiuna, ZHAI Shan, LI Xiaotian
doaj   +1 more source

PI3K and Notch signaling pathway play a synergistic regulatory role in the proliferation and activation of CD4+T cells in peripheral blood of patients with psoriasis vulgaris

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To study effects of phosphoinositide 3 kinase (PI3K) and Notch signaling pathway on the proliferation and activation of CD4+ T cells in peripheral blood of patients with psoriasis vulgaris.
Jia LIU, Ming WEI
doaj   +1 more source

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Gut Microbes, 2021
The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but somewhat interconnected significant immune pathways which play complex roles in a variety
Amir Hossein Mohseni, Vincenzo Casolaro, Luis G. Bermúdez-Humarán, Hossein Keyvani, Sedigheh Taghinezhad-S   +4 more
doaj   +1 more source

Mechanistic analysis of endothelial lipase G promotion of the occurrence and development of cervical carcinoma by activating the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B/mechanistic target of rapamycin kinase signalling pathway

Journal of Obstetrics and Gynaecology, 2023
Lipase G, endothelial type (LIPG) is expressed abundantly in tissues with a high metabolic rate and vascularisation. Research on LIPG has focussed on metabolic syndromes.
Jing Huang, Renci Liu, Yiwen Zhang, Xiujie Sheng   +3 more
doaj   +1 more source