Results 21 to 30 of about 626,720 (343)
EVALUATION OF PTEN AND PI3K/AKT EXPRESSIONS IN STANOZOLOL-TREATED RAT KIDNEYS
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: Stanozolol is an anabolic androgenic steroid (AAS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The potential effects of stanozolol in kidney functions have not been defined.
Tuğba Kotil +2 more
doaj +1 more source
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer
Frontiers in Pharmacology, 2021 Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease recurrence in most breast cancer patients, many patients exhibit acquired resistance.
Chao Dong +4 more
semanticscholar +1 more source
Успехи молекулярной онкологии, 2015 The basic contemporary data and the results of authors’ long-term personal research devoted to the role of auto / paracrine growth factors, their receptors and some down-stream signaling proteins (PI3K, Akt, NF-κB) in clinical course, prognosis and ...
E. S. Gershtein, N. E. Kushlinsky
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Platelets, 2022 Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
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Cardiac PI3K p110α attenuation delays aging and extends lifespan
Cell Stress, 2022 Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular metabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway extend the ...
Mahmoud Abdellatif +5 more
doaj +1 more source
Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy [PDF]
Journal of Integrative Neuroscience, 2021 Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer’s disease. The present paper’s goal was to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease.
Dong-Xing Liu +5 more
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PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
Cell Death and Disease, 2020 Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular signal cascades and regulates a variety of cellular processes.
Rui Liu +9 more
semanticscholar +1 more source
Cell Proliferation, 2022 Traumatic spinal cord injury (TSCI) causes neurological dysfunction below the injured segment of the spinal cord, which significantly impacts the quality of life in affected patients.
Xuegang He +8 more
semanticscholar +1 more source
Archives of Medical Science, 2022 Introduction Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore,
Jia-Ming Xu +7 more
doaj +1 more source
Effect of eight weeks of swimming training and CBD oil consumption on PI3K and ERK gene expression in the heart tissue of rats with myocardial infarction [PDF]
Journal of Shahrekord University of Medical Sciences, 2022 Background and aims: Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore,
Mostafa Safian Boldaji +2 more
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